A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Matthew S. Baker, Scott T. Phillips

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

Original languageEnglish (US)
Pages (from-to)5170-5173
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number14
DOIs
StatePublished - Apr 13 2011

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Palladium
Amplification
Assays
Molecules

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

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A two-component small molecule system for activity-based detection and signal amplification : Application to the visual detection of threshold levels of Pd(II). / Baker, Matthew S.; Phillips, Scott T.

In: Journal of the American Chemical Society, Vol. 133, No. 14, 13.04.2011, p. 5170-5173.

Research output: Contribution to journalArticle

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