A visible-light-promoted radical reaction system for azidation and halogenation of tertiary aliphatic C-H bonds

Yaxin Wang, Guo Xing Li, Guohui Yang, Gang He, Gong Chen

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

A highly tunable radical-mediated reaction system for the functionalization of tertiary aliphatic C-H bonds was developed. Reactions of various substrates with the Zhdankin azidoiodane reagent 1, Ru(bpy)3Cl2, and visible light irradiation at room temperature gave C-H azidated or halogenated products in an easily controllable fashion. These reactions are efficient, selective, and compatible with complex substrates. They provide a potentially valuable tool for selectively labeling tertiary C-H bonds of organic and biomolecules with tags of varied chemical and biophysical properties for comparative functional studies.

Original languageEnglish (US)
Pages (from-to)2679-2683
Number of pages5
JournalChemical Science
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2016

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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