TY - JOUR
T1 - Abdominal wall endometriosis in a rhesus macaque (Macaca mulatta)
AU - Atkins, Hannah M.
AU - Caudell, David L.
AU - Hutchison, A. Robert
AU - LeGrande, Andre C.
AU - Kock, Nancy D.
N1 - Funding Information:
We thank Lisa O'Donnell, Jean Gardin, Cathy Mathis, and Martha Ward (Comparative Pathology Laboratory, Wake Forest School of Medicine) for histology technical support. This case report was funded in part by NIH grant T32OD010957-37.
Publisher Copyright:
Copyright 2017 by the American Association for Laboratory Animal Science.
PY - 2017/6
Y1 - 2017/6
N2 - Endometriosis is the presence of endometrium outside of the uterus. Although endometriosis occurs in both pelvic and extrapelvic locations, extrapelvic locations are less common. The development of abdominal wall or incisional endometriosis in women is associated with gynecologic surgeries and is often misdiagnosed. Because they naturally develop endometriosis similar to women, Old World NHP, including rhesus macaques, provide excellent opportunities for studying endometriosis. Here, we describe a case of abdominal wall endometriosis in a rhesus macaque that had undergone cesarean section. Microscopically, the tissue consisted of pseudocolumnar epithelium-lined glands within a decidualized stroma, which dissected through the abdominal wall musculature and into the adjacent subcutaneous tissue. The stroma was strongly positive for vimentin and CD10 but was rarely, weakly positive for estrogen receptors and negative for progesterone. Close examination of extrapelvic endometriosis in rhesus macaques and other NHP may promote increased understanding of endometriosis in women.
AB - Endometriosis is the presence of endometrium outside of the uterus. Although endometriosis occurs in both pelvic and extrapelvic locations, extrapelvic locations are less common. The development of abdominal wall or incisional endometriosis in women is associated with gynecologic surgeries and is often misdiagnosed. Because they naturally develop endometriosis similar to women, Old World NHP, including rhesus macaques, provide excellent opportunities for studying endometriosis. Here, we describe a case of abdominal wall endometriosis in a rhesus macaque that had undergone cesarean section. Microscopically, the tissue consisted of pseudocolumnar epithelium-lined glands within a decidualized stroma, which dissected through the abdominal wall musculature and into the adjacent subcutaneous tissue. The stroma was strongly positive for vimentin and CD10 but was rarely, weakly positive for estrogen receptors and negative for progesterone. Close examination of extrapelvic endometriosis in rhesus macaques and other NHP may promote increased understanding of endometriosis in women.
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M3 - Article
C2 - 28662757
AN - SCOPUS:85021642528
VL - 67
SP - 277
EP - 280
JO - Comparative Medicine
JF - Comparative Medicine
SN - 1532-0820
IS - 3
ER -