@article{b195f824e46648789905abf699cdbd6c,
title = "Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia",
abstract = "Mutations and single nucleotide polymorphisms of AT-rich interactive domain-containing protein 5B (ARID5B) are involved in the oncogenesis of acute lymphoblastic leukemia (ALL) and treatment outcomes. However, ARID5B expression and clinical significance in ALL remain unclear. We found ARID5B is significantly down-regulated in ALL compared to healthy bone marrow controls. ARID5B also interacts with PHD finger protein 2 (PHF2). Low expression of ARID5B (ARID5Blow) or ARID5B and PHF2 (ARID5BlowPHF2low) is correlated with the markers of cell proliferation and poor prognosis in ALL patients. Ikaros directly regulates ARID5B expression in ALL. Restoring Ikaros function by Casein Kinase II inhibition also promotes ARID5B expression through recruitment of trimethylation of lysine 4 on histone H3 (H3K4me3) at its promoter region. In summary, our data show that aberrant expression of ARID5B and PHF2 is related to leukemic cell proliferation and several poor prognostic markers. Our data indicate ARID5Blow expression, particularly ARID5BlowPHF2low expression, is linked to Ikaros dysfunction and involved in the oncogenic effect of high-risk ALL, which may represent a high-risk subgroup of ALL.",
author = "Zheng Ge and Qi Han and Yan Gu and Qinyu Ge and Jinlong Ma and Justin Sloane and Guofeng Gao and Payne, {Kimberly J.} and Laszlo Szekely and Chunhua Song and Sinisa Dovat",
note = "Funding Information: This work is supported in part by Key Research and Technology Projects in Jiangsu Province (BE2017747); Milstein Medical Asian American Partnership (MMAAP) Foundation Research Project Award in Hematology (2017); The National Natural Science Foundation of China (81770172, 81270613); The Fundamental Research Funds for the Central Universities (2242017K40271, 2242016K40143); The Scientific Research Foundation for the Returned Overseas Chinese Scholars; State Education Ministry (39th); China Postdoctoral Science Foundation (20090461134); Jiangsu Province Key Medical Talents (RC2011077); Special grade of the financial support from China Postdoctoral Science Foundation (201003598); The Six Great Talent Peak Plan of Jiangsu (2010-WS-024) (to Z.G.). This work has also been partially supported by National Institutes of Health (NIH), National Cancer Institute (NCI) grants R01CA209829, (K.J.P. and S.D.) R01CA213912, Hyundai Hope on Wheels Scholar Grant, the Four Diamonds Fund of the Pennsylvania State University College of Medicine (to S. D. and C.S.); Bear Necessities Pediatric Cancer Foundation, Alex{\textquoteright}s Lemonade Stand Foundation, and the John Wawrynovic Leukemia Research Scholar Endowment (to S.D.). Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = nov,
day = "1",
doi = "10.1038/s41389-018-0095-x",
language = "English (US)",
volume = "7",
journal = "Oncogenesis",
issn = "2157-9024",
publisher = "Nature Publishing Group",
number = "11",
}