Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus

Alyson I. Swimm, William Bornmann, Mengxi Jiang, Michael J. Imperiale, Aron E. Lukacher, Daniel Kalman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Sialylated lipids serve as cellular receptors for polyomaviruses. Using pharmacological inhibitors and cell lines derived from knockout mice, we demonstrate that Abl family tyrosine kinases are required for replication of mouse polyomavirus and BK virus, a human polyomavirus associated with allograft failure following kidney transplantation. We show that decreasing Abl family kinase activity results in low levels of cell surface ganglioside receptors for mouse polyomavirus and that inhibition of sialidase activity promotes virion binding in the absence of Abl family kinase activity. These data provide evidence that Abl family kinases reduce ganglioside turnover in the plasma membrane by inhibiting host cell sialidase activity. Thus, Abl family kinases regulate the susceptibility of cells to polyomavirus infection by modulating gangliosides required for viral attachment.

Original languageEnglish (US)
Pages (from-to)4243-4251
Number of pages9
JournalJournal of virology
Volume84
Issue number9
DOIs
StatePublished - May 1 2010

Fingerprint

Polyomavirus
gangliosides
Protein-Tyrosine Kinases
tyrosine
phosphotransferases (kinases)
Phosphotransferases
Murine polyomavirus
receptors
Gangliosides
Neuraminidase
sialidase
Polyomavirus Infections
Polyomaviridae
BK Virus
Cell Surface Receptors
vertebrate viruses
kidney transplant
Knockout Mice
allografting
Virion

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Swimm, Alyson I. ; Bornmann, William ; Jiang, Mengxi ; Imperiale, Michael J. ; Lukacher, Aron E. ; Kalman, Daniel. / Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus. In: Journal of virology. 2010 ; Vol. 84, No. 9. pp. 4243-4251.
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Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus. / Swimm, Alyson I.; Bornmann, William; Jiang, Mengxi; Imperiale, Michael J.; Lukacher, Aron E.; Kalman, Daniel.

In: Journal of virology, Vol. 84, No. 9, 01.05.2010, p. 4243-4251.

Research output: Contribution to journalArticle

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AU - Swimm, Alyson I.

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AU - Kalman, Daniel

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AB - Sialylated lipids serve as cellular receptors for polyomaviruses. Using pharmacological inhibitors and cell lines derived from knockout mice, we demonstrate that Abl family tyrosine kinases are required for replication of mouse polyomavirus and BK virus, a human polyomavirus associated with allograft failure following kidney transplantation. We show that decreasing Abl family kinase activity results in low levels of cell surface ganglioside receptors for mouse polyomavirus and that inhibition of sialidase activity promotes virion binding in the absence of Abl family kinase activity. These data provide evidence that Abl family kinases reduce ganglioside turnover in the plasma membrane by inhibiting host cell sialidase activity. Thus, Abl family kinases regulate the susceptibility of cells to polyomavirus infection by modulating gangliosides required for viral attachment.

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