Abnormal Regional Homogeneity in Patients with Essential Tremor Revealed by Resting-State Functional MRI

Weidong Fang, Fajin Lv, Tianyou Luo, Oumei Cheng, Wei Liao, Ke Sheng, Xuefeng Wang, Fei Wu, Yida Hu, Jing Luo, Qing Yang, Han Zhang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Essential tremor (ET) is one of the most common movement disorders in human adults. It can be characterized as a progressive neurological disorder of which the most recognizable feature is a tremor of the arms or hands that is apparent during voluntary movements such as eating and writing. The pathology of ET remains unclear. Resting-state fMRI (RS-fMRI), as a non-invasive imaging technique, was employed to investigate abnormalities of functional connectivity in ET in the brain. Regional homogeneity (ReHo) was used as a metric of RS-fMRI to assess the local functional connectivity abnormality in ET with 20 ET patients and 20 age- and gender-matched healthy controls (HC). The ET group showed decreased ReHo in the anterior and posterior bilateral cerebellar lobes, the bilateral thalamus and the insular lobe, and increased ReHo in the bilateral prefrontal and parietal cortices, the left primary motor cortex and left supplementary motor area. The abnormal ReHo value of ET patients in the bilateral anterior cerebellar lobes and the right posterior cerebellar lobe were negatively correlated with the tremor severity score, while positively correlated with that in the left primary motor cortex. These findings suggest that the abnormality in cerebello-thalamo-cortical motor pathway is involved in tremor generation and propagation, which may be related to motor-related symptoms in ET patients. Meanwhile, the abnormality in the prefrontal and parietal regions may be associated with non-motor symptoms in ET. These findings suggest that the ReHo could be utilized for investigations of functional-pathological mechanism of ET.

Original languageEnglish (US)
Article numbere69199
JournalPloS one
Volume8
Issue number7
DOIs
StatePublished - Jul 15 2013

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Essential Tremor
Magnetic Resonance Imaging
signs and symptoms (animals and humans)
movement disorders
thalamus
nervous system diseases
Motor Cortex
Tremor
cortex
hands
Parietal Lobe
ingestion
image analysis
brain
Pathology
gender
Brain
Efferent Pathways
Imaging techniques
Movement Disorders

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Fang, Weidong ; Lv, Fajin ; Luo, Tianyou ; Cheng, Oumei ; Liao, Wei ; Sheng, Ke ; Wang, Xuefeng ; Wu, Fei ; Hu, Yida ; Luo, Jing ; Yang, Qing ; Zhang, Han. / Abnormal Regional Homogeneity in Patients with Essential Tremor Revealed by Resting-State Functional MRI. In: PloS one. 2013 ; Vol. 8, No. 7.
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title = "Abnormal Regional Homogeneity in Patients with Essential Tremor Revealed by Resting-State Functional MRI",
abstract = "Essential tremor (ET) is one of the most common movement disorders in human adults. It can be characterized as a progressive neurological disorder of which the most recognizable feature is a tremor of the arms or hands that is apparent during voluntary movements such as eating and writing. The pathology of ET remains unclear. Resting-state fMRI (RS-fMRI), as a non-invasive imaging technique, was employed to investigate abnormalities of functional connectivity in ET in the brain. Regional homogeneity (ReHo) was used as a metric of RS-fMRI to assess the local functional connectivity abnormality in ET with 20 ET patients and 20 age- and gender-matched healthy controls (HC). The ET group showed decreased ReHo in the anterior and posterior bilateral cerebellar lobes, the bilateral thalamus and the insular lobe, and increased ReHo in the bilateral prefrontal and parietal cortices, the left primary motor cortex and left supplementary motor area. The abnormal ReHo value of ET patients in the bilateral anterior cerebellar lobes and the right posterior cerebellar lobe were negatively correlated with the tremor severity score, while positively correlated with that in the left primary motor cortex. These findings suggest that the abnormality in cerebello-thalamo-cortical motor pathway is involved in tremor generation and propagation, which may be related to motor-related symptoms in ET patients. Meanwhile, the abnormality in the prefrontal and parietal regions may be associated with non-motor symptoms in ET. These findings suggest that the ReHo could be utilized for investigations of functional-pathological mechanism of ET.",
author = "Weidong Fang and Fajin Lv and Tianyou Luo and Oumei Cheng and Wei Liao and Ke Sheng and Xuefeng Wang and Fei Wu and Yida Hu and Jing Luo and Qing Yang and Han Zhang",
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Fang, W, Lv, F, Luo, T, Cheng, O, Liao, W, Sheng, K, Wang, X, Wu, F, Hu, Y, Luo, J, Yang, Q & Zhang, H 2013, 'Abnormal Regional Homogeneity in Patients with Essential Tremor Revealed by Resting-State Functional MRI', PloS one, vol. 8, no. 7, e69199. https://doi.org/10.1371/journal.pone.0069199

Abnormal Regional Homogeneity in Patients with Essential Tremor Revealed by Resting-State Functional MRI. / Fang, Weidong; Lv, Fajin; Luo, Tianyou; Cheng, Oumei; Liao, Wei; Sheng, Ke; Wang, Xuefeng; Wu, Fei; Hu, Yida; Luo, Jing; Yang, Qing; Zhang, Han.

In: PloS one, Vol. 8, No. 7, e69199, 15.07.2013.

Research output: Contribution to journalArticle

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T1 - Abnormal Regional Homogeneity in Patients with Essential Tremor Revealed by Resting-State Functional MRI

AU - Fang, Weidong

AU - Lv, Fajin

AU - Luo, Tianyou

AU - Cheng, Oumei

AU - Liao, Wei

AU - Sheng, Ke

AU - Wang, Xuefeng

AU - Wu, Fei

AU - Hu, Yida

AU - Luo, Jing

AU - Yang, Qing

AU - Zhang, Han

PY - 2013/7/15

Y1 - 2013/7/15

N2 - Essential tremor (ET) is one of the most common movement disorders in human adults. It can be characterized as a progressive neurological disorder of which the most recognizable feature is a tremor of the arms or hands that is apparent during voluntary movements such as eating and writing. The pathology of ET remains unclear. Resting-state fMRI (RS-fMRI), as a non-invasive imaging technique, was employed to investigate abnormalities of functional connectivity in ET in the brain. Regional homogeneity (ReHo) was used as a metric of RS-fMRI to assess the local functional connectivity abnormality in ET with 20 ET patients and 20 age- and gender-matched healthy controls (HC). The ET group showed decreased ReHo in the anterior and posterior bilateral cerebellar lobes, the bilateral thalamus and the insular lobe, and increased ReHo in the bilateral prefrontal and parietal cortices, the left primary motor cortex and left supplementary motor area. The abnormal ReHo value of ET patients in the bilateral anterior cerebellar lobes and the right posterior cerebellar lobe were negatively correlated with the tremor severity score, while positively correlated with that in the left primary motor cortex. These findings suggest that the abnormality in cerebello-thalamo-cortical motor pathway is involved in tremor generation and propagation, which may be related to motor-related symptoms in ET patients. Meanwhile, the abnormality in the prefrontal and parietal regions may be associated with non-motor symptoms in ET. These findings suggest that the ReHo could be utilized for investigations of functional-pathological mechanism of ET.

AB - Essential tremor (ET) is one of the most common movement disorders in human adults. It can be characterized as a progressive neurological disorder of which the most recognizable feature is a tremor of the arms or hands that is apparent during voluntary movements such as eating and writing. The pathology of ET remains unclear. Resting-state fMRI (RS-fMRI), as a non-invasive imaging technique, was employed to investigate abnormalities of functional connectivity in ET in the brain. Regional homogeneity (ReHo) was used as a metric of RS-fMRI to assess the local functional connectivity abnormality in ET with 20 ET patients and 20 age- and gender-matched healthy controls (HC). The ET group showed decreased ReHo in the anterior and posterior bilateral cerebellar lobes, the bilateral thalamus and the insular lobe, and increased ReHo in the bilateral prefrontal and parietal cortices, the left primary motor cortex and left supplementary motor area. The abnormal ReHo value of ET patients in the bilateral anterior cerebellar lobes and the right posterior cerebellar lobe were negatively correlated with the tremor severity score, while positively correlated with that in the left primary motor cortex. These findings suggest that the abnormality in cerebello-thalamo-cortical motor pathway is involved in tremor generation and propagation, which may be related to motor-related symptoms in ET patients. Meanwhile, the abnormality in the prefrontal and parietal regions may be associated with non-motor symptoms in ET. These findings suggest that the ReHo could be utilized for investigations of functional-pathological mechanism of ET.

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