Abnormal Respiratory Control in Acquired Dysautonomia

John H. Eisele, Carroll E. Cross, David C. Rausch, Cornelis J. Kurpershoek, Robert Zelis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In a patient with acquired dysautonomia respiratory as well as circulatory control mechanisms were abnormal. In response to breathing of 10 per cent oxygen in nitrogen there was no respiratory drive, and at the same time the arterial-blood pressure fell, indicating the absence or failure of peripheral chemoreceptor function. Abnormal blood-pressure responses to tilting and Valsalva maneuvers showed a lack of sympathetic vasoconstriction, whereas the pupillary and cardiac responses to methacholine and atropine indicated parasympathetic nervous-system impairment. The ventilatory response to carbon dioxide was weak — a fact that may or may not mean central chemoreceptor involvement. The normal rapid breathing response at the onset of exercise developed in spite of the lack of sympathetic nervous and peripheral chemoreceptor functions.

Original languageEnglish (US)
Pages (from-to)366-368
Number of pages3
JournalNew England Journal of Medicine
Volume285
Issue number7
DOIs
StatePublished - Aug 12 1971

Fingerprint

Primary Dysautonomias
Respiration
Parasympathetic Nervous System
Valsalva Maneuver
Methacholine Chloride
Vasoconstriction
Atropine
Carbon Dioxide
Arterial Pressure
Nitrogen
Exercise
Oxygen
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Eisele, John H. ; Cross, Carroll E. ; Rausch, David C. ; Kurpershoek, Cornelis J. ; Zelis, Robert. / Abnormal Respiratory Control in Acquired Dysautonomia. In: New England Journal of Medicine. 1971 ; Vol. 285, No. 7. pp. 366-368.
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Eisele, JH, Cross, CE, Rausch, DC, Kurpershoek, CJ & Zelis, R 1971, 'Abnormal Respiratory Control in Acquired Dysautonomia', New England Journal of Medicine, vol. 285, no. 7, pp. 366-368. https://doi.org/10.1056/NEJM197108122850702

Abnormal Respiratory Control in Acquired Dysautonomia. / Eisele, John H.; Cross, Carroll E.; Rausch, David C.; Kurpershoek, Cornelis J.; Zelis, Robert.

In: New England Journal of Medicine, Vol. 285, No. 7, 12.08.1971, p. 366-368.

Research output: Contribution to journalArticle

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