Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia

Julian Fagerli, Francis X. Schneck, Peter Lee, Mark F. Bellinger, Selma F. Witchel

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To determine if cryptorchidism is associate with microdeletions of interval 6 of the Y chromosome, we evaluated this locus in men with a history of cryptorchidism with and without azoospermia or oligospermia and in a control group. Design: Clinical study. Setting: Academic research environment. Patient(s): Men in whom surgical treatment of cryptorchidism had been performed in childhood and healthy control male subjects. Intervention(s): None. Main Outcome Measure(s): Genotyping of interval 6 of the Y chromosome. Results(s): Analysing of semen obtained from men treated for cryptorchidism in childhood showed azoospermia or oligospermia in 14 of 38 (37%) men. No microdeletions were identified with polymerase chain reaction amplification of 17 distinct sequence tagged sites located on the long arm of the Y chromosome and the sex determining region on Y (SRY) gene. Conclusion(s): Microdeletions of interval 6 of the Y chromosome were not detected in either the formerly cryptorchid or in the healthy subjects. Although we cannot exclude the possibility of point mutations, we microdeletions involving interval 6 of the Y chromosome.

Original languageEnglish (US)
Pages (from-to)697-700
Number of pages4
JournalFertility and sterility
Volume71
Issue number4
DOIs
StatePublished - Apr 1 1999

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Oligospermia
Azoospermia
Cryptorchidism
Y Chromosome
sry Genes
Sequence Tagged Sites
Semen
Point Mutation
Healthy Volunteers
Outcome Assessment (Health Care)
Male sterility due to Y-chromosome deletions
Polymerase Chain Reaction
Control Groups
Research

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Fagerli, Julian ; Schneck, Francis X. ; Lee, Peter ; Bellinger, Mark F. ; Witchel, Selma F. / Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. In: Fertility and sterility. 1999 ; Vol. 71, No. 4. pp. 697-700.
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Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. / Fagerli, Julian; Schneck, Francis X.; Lee, Peter; Bellinger, Mark F.; Witchel, Selma F.

In: Fertility and sterility, Vol. 71, No. 4, 01.04.1999, p. 697-700.

Research output: Contribution to journalArticle

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