TY - JOUR
T1 - Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct-cannulated rats
AU - Traber, M. G.
AU - Kayden, H. J.
AU - Green, J. B.
AU - Green, M. H.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - Oral administration of vitamin E (100 mg tocopherol · kg-1 · day-1) as tocopheryl polyethylene glycol 1000 succinate (TPGS) to a child with congenital hepatic cholestasis (unresponsive to oral administration of dl-α-tocopheryl acetate) promoted an increase of tocopherol in plasma and adipose tissue while tocopheryl acetate emulsified with medium chain triglycerides and polysorbate 80 (MCT-E) did not. α-Tocopherol absorption, quantitated in thoracic duct-cannulated rats receiving intraduodenal infusions of soybean oil and saline, was similar for TPGS, MCT-E and dl-α-tocopheryl acetate; γ-tocopherol absorption from soybean oil was not affected by the presence of the supplemented 1/2 -tocopherol. Following bile duct ligation in one rat. TPGS promoted the absorption of α-tocopherol while absorption of γ-tocopherol from soybean oil was decreased 30 fold, demonstrating that TPGS, which forms a micellar solution, delivers α-tocopherol through the unstirred water layer to enterocytes, while free tocopherol (α or γ) absorption requires the presence of bile salts.
AB - Oral administration of vitamin E (100 mg tocopherol · kg-1 · day-1) as tocopheryl polyethylene glycol 1000 succinate (TPGS) to a child with congenital hepatic cholestasis (unresponsive to oral administration of dl-α-tocopheryl acetate) promoted an increase of tocopherol in plasma and adipose tissue while tocopheryl acetate emulsified with medium chain triglycerides and polysorbate 80 (MCT-E) did not. α-Tocopherol absorption, quantitated in thoracic duct-cannulated rats receiving intraduodenal infusions of soybean oil and saline, was similar for TPGS, MCT-E and dl-α-tocopheryl acetate; γ-tocopherol absorption from soybean oil was not affected by the presence of the supplemented 1/2 -tocopherol. Following bile duct ligation in one rat. TPGS promoted the absorption of α-tocopherol while absorption of γ-tocopherol from soybean oil was decreased 30 fold, demonstrating that TPGS, which forms a micellar solution, delivers α-tocopherol through the unstirred water layer to enterocytes, while free tocopherol (α or γ) absorption requires the presence of bile salts.
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U2 - 10.1093/ajcn/44.6.914
DO - 10.1093/ajcn/44.6.914
M3 - Article
C2 - 3788838
AN - SCOPUS:0022982286
VL - 44
SP - 914
EP - 923
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 6
ER -