Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct-cannulated rats

M. G. Traber, H. J. Kayden, J. B. Green, M. H. Green

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Abstract

Oral administration of vitamin E (100 mg tocopherol · kg-1 · day-1) as tocopheryl polyethylene glycol 1000 succinate (TPGS) to a child with congenital hepatic cholestasis (unresponsive to oral administration of dl-α-tocopheryl acetate) promoted an increase of tocopherol in plasma and adipose tissue while tocopheryl acetate emulsified with medium chain triglycerides and polysorbate 80 (MCT-E) did not. α-Tocopherol absorption, quantitated in thoracic duct-cannulated rats receiving intraduodenal infusions of soybean oil and saline, was similar for TPGS, MCT-E and dl-α-tocopheryl acetate; γ-tocopherol absorption from soybean oil was not affected by the presence of the supplemented 1/2 -tocopherol. Following bile duct ligation in one rat. TPGS promoted the absorption of α-tocopherol while absorption of γ-tocopherol from soybean oil was decreased 30 fold, demonstrating that TPGS, which forms a micellar solution, delivers α-tocopherol through the unstirred water layer to enterocytes, while free tocopherol (α or γ) absorption requires the presence of bile salts.

Original languageEnglish (US)
Pages (from-to)914-923
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume44
Issue number6
DOIs
StatePublished - Jan 1 1986

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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