Accidental subretinal brilliant blue G migration during internal limiting membrane peeling surgery

Felipe P.P. Almeida, Ana Claudia De Lucca, Ingrid Ursula Scott, Rodrigo Jorge, Andre Messias

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

IMPORTANCE: This case report describes a man who developed retinal changes in his right eye associated with brilliant blue G migration into the subretinal space during 2 years of follow-up. OBSERVATION: The patient's best-corrected visual acuity in the right eye was 20/70 before surgery, and it improved to 20/25 at 1 year after surgery. Fluorescein angiography showed staining during the late phase in the central macula at all follow-up visits after surgery. Multifocal electroretinography demonstrated normal amplitude and implicit times before surgery but decreased amplitudes and increased implicit times in at least 5 contiguous hexagons after surgery on all 3 examinations performed during the 2-year follow-up period. These functional changes were not topographically correlated with the area of fluorescein staining or with the internal limiting membrane peeled area, but were matched to the area where brilliant blue G accidentally entered the subretinal space. Microperimetry demonstrated reduced retinal threshold sensitivity, particularly in areas with decreased multifocal electroretinography amplitude. CONCLUSIONS AND RELEVANCE: Despite the visual acuity improvement observed in this case, multifocal electroretinography and microperimetry indicate that subretinal brilliant blue G might cause focal macular damage with a decrease of macular function suggestive of a toxic effect.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalJAMA Ophthalmology
Volume133
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Electroretinography
Membranes
Visual Acuity
Staining and Labeling
Fluorescein Angiography
Poisons
Fluorescein
Observation
coomassie Brilliant Blue

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Almeida, Felipe P.P. ; De Lucca, Ana Claudia ; Scott, Ingrid Ursula ; Jorge, Rodrigo ; Messias, Andre. / Accidental subretinal brilliant blue G migration during internal limiting membrane peeling surgery. In: JAMA Ophthalmology. 2015 ; Vol. 133, No. 1. pp. 85-88.
@article{944b52ec66b44bedb3c72f9073780086,
title = "Accidental subretinal brilliant blue G migration during internal limiting membrane peeling surgery",
abstract = "IMPORTANCE: This case report describes a man who developed retinal changes in his right eye associated with brilliant blue G migration into the subretinal space during 2 years of follow-up. OBSERVATION: The patient's best-corrected visual acuity in the right eye was 20/70 before surgery, and it improved to 20/25 at 1 year after surgery. Fluorescein angiography showed staining during the late phase in the central macula at all follow-up visits after surgery. Multifocal electroretinography demonstrated normal amplitude and implicit times before surgery but decreased amplitudes and increased implicit times in at least 5 contiguous hexagons after surgery on all 3 examinations performed during the 2-year follow-up period. These functional changes were not topographically correlated with the area of fluorescein staining or with the internal limiting membrane peeled area, but were matched to the area where brilliant blue G accidentally entered the subretinal space. Microperimetry demonstrated reduced retinal threshold sensitivity, particularly in areas with decreased multifocal electroretinography amplitude. CONCLUSIONS AND RELEVANCE: Despite the visual acuity improvement observed in this case, multifocal electroretinography and microperimetry indicate that subretinal brilliant blue G might cause focal macular damage with a decrease of macular function suggestive of a toxic effect.",
author = "Almeida, {Felipe P.P.} and {De Lucca}, {Ana Claudia} and Scott, {Ingrid Ursula} and Rodrigo Jorge and Andre Messias",
year = "2015",
month = "1",
day = "1",
doi = "10.1001/jamaophthalmol.2014.3869",
language = "English (US)",
volume = "133",
pages = "85--88",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "1",

}

Accidental subretinal brilliant blue G migration during internal limiting membrane peeling surgery. / Almeida, Felipe P.P.; De Lucca, Ana Claudia; Scott, Ingrid Ursula; Jorge, Rodrigo; Messias, Andre.

In: JAMA Ophthalmology, Vol. 133, No. 1, 01.01.2015, p. 85-88.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Accidental subretinal brilliant blue G migration during internal limiting membrane peeling surgery

AU - Almeida, Felipe P.P.

AU - De Lucca, Ana Claudia

AU - Scott, Ingrid Ursula

AU - Jorge, Rodrigo

AU - Messias, Andre

PY - 2015/1/1

Y1 - 2015/1/1

N2 - IMPORTANCE: This case report describes a man who developed retinal changes in his right eye associated with brilliant blue G migration into the subretinal space during 2 years of follow-up. OBSERVATION: The patient's best-corrected visual acuity in the right eye was 20/70 before surgery, and it improved to 20/25 at 1 year after surgery. Fluorescein angiography showed staining during the late phase in the central macula at all follow-up visits after surgery. Multifocal electroretinography demonstrated normal amplitude and implicit times before surgery but decreased amplitudes and increased implicit times in at least 5 contiguous hexagons after surgery on all 3 examinations performed during the 2-year follow-up period. These functional changes were not topographically correlated with the area of fluorescein staining or with the internal limiting membrane peeled area, but were matched to the area where brilliant blue G accidentally entered the subretinal space. Microperimetry demonstrated reduced retinal threshold sensitivity, particularly in areas with decreased multifocal electroretinography amplitude. CONCLUSIONS AND RELEVANCE: Despite the visual acuity improvement observed in this case, multifocal electroretinography and microperimetry indicate that subretinal brilliant blue G might cause focal macular damage with a decrease of macular function suggestive of a toxic effect.

AB - IMPORTANCE: This case report describes a man who developed retinal changes in his right eye associated with brilliant blue G migration into the subretinal space during 2 years of follow-up. OBSERVATION: The patient's best-corrected visual acuity in the right eye was 20/70 before surgery, and it improved to 20/25 at 1 year after surgery. Fluorescein angiography showed staining during the late phase in the central macula at all follow-up visits after surgery. Multifocal electroretinography demonstrated normal amplitude and implicit times before surgery but decreased amplitudes and increased implicit times in at least 5 contiguous hexagons after surgery on all 3 examinations performed during the 2-year follow-up period. These functional changes were not topographically correlated with the area of fluorescein staining or with the internal limiting membrane peeled area, but were matched to the area where brilliant blue G accidentally entered the subretinal space. Microperimetry demonstrated reduced retinal threshold sensitivity, particularly in areas with decreased multifocal electroretinography amplitude. CONCLUSIONS AND RELEVANCE: Despite the visual acuity improvement observed in this case, multifocal electroretinography and microperimetry indicate that subretinal brilliant blue G might cause focal macular damage with a decrease of macular function suggestive of a toxic effect.

UR - http://www.scopus.com/inward/record.url?scp=84920972997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920972997&partnerID=8YFLogxK

U2 - 10.1001/jamaophthalmol.2014.3869

DO - 10.1001/jamaophthalmol.2014.3869

M3 - Article

C2 - 25321324

AN - SCOPUS:84920972997

VL - 133

SP - 85

EP - 88

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 1

ER -