Acetylcholine-induced contractions in a holothurian (Isostichopus badionotus) smooth muscle are blocked by the calcium antagonists, diltiazem and verapamil

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Abstract

1. The longitudinal muscle of the body wall (LMBW) of the holothurian, Isostichopus badionotus contracted when treated with acetylcholine (ACh). The threshold concentration for initiating a contraction was 10-8M ACh. 2. Inward calcium (Ca2+) current blockers, diltiazem and verapamil, blocked contractions induced by ACh suggesting that Ca2+ channels are involved. Verapamil caused small rhythmic contractions to occur in some muscle preparations. 3. Caffeine initiated contractions only at the high concentration of 10 mM and caused rhythmic contractions in otherwise non-spontaneously beating muscle. The caffeine-contractions were partially blocked by verapamil.

Original languageEnglish (US)
Pages (from-to)573-577
Number of pages5
JournalComparative Biochemistry and Physiology. Part C: Comparative
Volume106
Issue number2
DOIs
StatePublished - Oct 1993

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

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