Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification

Liqun Ma, Xuexin Zhang, Min Zhou, Haijun Chen

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Background: Two-pore domain K+ channels mediate background K+ conductance and regulate cellular function. Results: Low extracellular pH (pHo) significantly increases the Na+ to K+ relative permeability of TWIK-1, TASK-1, and TASK-3 K+ channels. Conclusion: TWIK-1, TASK-1, and TASK-3 channels change ion selectivity in lowered pHo. Significance: The findings provide insights on the mechanism of regulation of acid-sensitive K2P channels by low pHo.

Original languageEnglish (US)
Pages (from-to)37145-37153
Number of pages9
JournalJournal of Biological Chemistry
Issue number44
Publication statusPublished - Oct 26 2012


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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