Background: Two-pore domain K+ channels mediate background K+ conductance and regulate cellular function. Results: Low extracellular pH (pHo) significantly increases the Na+ to K+ relative permeability of TWIK-1, TASK-1, and TASK-3 K+ channels. Conclusion: TWIK-1, TASK-1, and TASK-3 channels change ion selectivity in lowered pHo. Significance: The findings provide insights on the mechanism of regulation of acid-sensitive K2P channels by low pHo.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology