Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

Ryan P. Hobbs, Susan H. Smith, Spiro Getsios

Research output: Contribution to journalComment/debate

2 Scopus citations

Abstract

Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

Original languageEnglish (US)
Pages (from-to)1410-1412
Number of pages3
JournalJournal of Investigative Dermatology
Volume137
Issue number7
DOIs
StatePublished - Jul 2017

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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