Act1

A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

Ryan Hobbs, Susan H. Smith, Spiro Getsios

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

Original languageEnglish (US)
Pages (from-to)1410-1412
Number of pages3
JournalJournal of Investigative Dermatology
Volume137
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Keratinocytes
Psoriasis
Interleukin-17 Receptors
Genes
Transcriptome
Innate Immunity
RNA
Inflammation
Genetics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Hobbs, Ryan ; Smith, Susan H. ; Getsios, Spiro. / Act1 : A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes. In: Journal of Investigative Dermatology. 2017 ; Vol. 137, No. 7. pp. 1410-1412.
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Act1 : A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes. / Hobbs, Ryan; Smith, Susan H.; Getsios, Spiro.

In: Journal of Investigative Dermatology, Vol. 137, No. 7, 01.07.2017, p. 1410-1412.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Act1

T2 - A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

AU - Hobbs, Ryan

AU - Smith, Susan H.

AU - Getsios, Spiro

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

AB - Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

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DO - 10.1016/j.jid.2017.01.023

M3 - Comment/debate

VL - 137

SP - 1410

EP - 1412

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

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ER -