ACTH stimulation tests in women with hirsutism

Didier Dewailly, Selma F. Siegel, David Finegold, Peter Lee

Research output: Contribution to journalLetter

1 Citation (Scopus)

Abstract

To the Editor: The paper by Siegel et al. (Sept. 27 issue)1 raises a question about the interpretation of the results of ACTH stimulation tests in women with hirsutism. An excessive response (i.e., an increase to a value >2 SD above the mean in normal women) of either plasma 17-hydroxyprogesterone or 17-hydroxypregnenolone may not be specific enough to categorize a woman as having lateonset congenital adrenal hyperplasia due to 21-hydroxylase deficiency or 3β-hydroxysteroid dehydrogenase deficiency. A biochemical response above a statistically defined threshold is an arbitrary screening index and should not be considered a specific phenotypic feature of disease. In. . .

Original languageEnglish (US)
Pages (from-to)564-565
Number of pages2
JournalNew England Journal of Medicine
Volume324
Issue number8
DOIs
StatePublished - Feb 21 1991

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Hirsutism
Adrenocorticotropic Hormone
17-alpha-Hydroxypregnenolone
3-Hydroxysteroid Dehydrogenases
17-alpha-Hydroxyprogesterone

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Dewailly, Didier ; Siegel, Selma F. ; Finegold, David ; Lee, Peter. / ACTH stimulation tests in women with hirsutism. In: New England Journal of Medicine. 1991 ; Vol. 324, No. 8. pp. 564-565.
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ACTH stimulation tests in women with hirsutism. / Dewailly, Didier; Siegel, Selma F.; Finegold, David; Lee, Peter.

In: New England Journal of Medicine, Vol. 324, No. 8, 21.02.1991, p. 564-565.

Research output: Contribution to journalLetter

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AU - Siegel, Selma F.

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AU - Lee, Peter

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