Actin depolymerization transduces the strength of B-cell receptor stimulation

Shengli Hao, Avery August

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Polymerization of the actin cytoskeleton has been found to be essential for B-cell activation. We show here, however, that stimulation of BCR induces a rapid global actin depolymerization in a BCR signal strength-dependent manner, followed by polarized actin repolymerization. Depolymerization of actin enhances and blocking actin depolymerization inhibits BCR signaling, leading to altered BCR and lipid raft clustering, ERK activation, and transcription factor activation. Furthermore actin depolymerization by itself induces altered lipid raft clustering and ERK activation, suggesting that F-actin may play a role in separating lipid rafts and in setting the threshold for cellular activation.

Original languageEnglish (US)
Pages (from-to)2275-2284
Number of pages10
JournalMolecular biology of the cell
Volume16
Issue number5
DOIs
StatePublished - May 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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