Action of insulin at the nuclear envelope

I. D. Goldfine, Gary Clawson, E. A. Smuckler, F. Purrello, R. Vigneri

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Insulin binding sites are present on purified nuclear envelopes from liver and other tissues, and EM autoradiographs and other types of studies indicate that insulin can enter intact target cells and interact with several types of intracellular membranes, including the nuclear envelope. More recent studies indicate that insulin has direct effects on both mRNA efflux from isolated nuclei and nuclear envelope NTPase, the enzyme that regulates mRNA efflux. These studies raise the possibility, therefore, that insulin regulates mRNA levels in target cells by directly influencing nuclear membrane functions as NTPase. Since insulin does not dramatically elevate mRNA levels for all proteins, the question arises as to how insulin selectively increases mRNA for specific mRNAs. One possibility is that there is targeting of specific mRNA molecules for specific pore complexes and that insulin may only influence a certain fraction of the nuclear pores. Thus, continued investigation is needed concerning the role of polypeptide hormones such as insulin in nucleocytoplasmic exchange.

Original languageEnglish (US)
Pages (from-to)3-14
Number of pages12
JournalMolecular and Cellular Biochemistry
Volume107
Issue number2
DOIs
StatePublished - Oct 1 1991

Fingerprint

Nuclear Envelope
Insulin
Messenger RNA
Nucleoside-Triphosphatase
Membranes
Nuclear Pore
Intracellular Membranes
Peptide Hormones
Liver
Binding Sites
Tissue
Molecules
Enzymes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Goldfine, I. D., Clawson, G., Smuckler, E. A., Purrello, F., & Vigneri, R. (1991). Action of insulin at the nuclear envelope. Molecular and Cellular Biochemistry, 107(2), 3-14. https://doi.org/10.1007/BF00214816
Goldfine, I. D. ; Clawson, Gary ; Smuckler, E. A. ; Purrello, F. ; Vigneri, R. / Action of insulin at the nuclear envelope. In: Molecular and Cellular Biochemistry. 1991 ; Vol. 107, No. 2. pp. 3-14.
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Goldfine, ID, Clawson, G, Smuckler, EA, Purrello, F & Vigneri, R 1991, 'Action of insulin at the nuclear envelope', Molecular and Cellular Biochemistry, vol. 107, no. 2, pp. 3-14. https://doi.org/10.1007/BF00214816

Action of insulin at the nuclear envelope. / Goldfine, I. D.; Clawson, Gary; Smuckler, E. A.; Purrello, F.; Vigneri, R.

In: Molecular and Cellular Biochemistry, Vol. 107, No. 2, 01.10.1991, p. 3-14.

Research output: Contribution to journalArticle

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