Activated natural killer cells adhere to cultured hippocampal neurons and affect the dendritic morphology

Sanae Hasegawa, Masahiro Yamaguchi, Hiroshi Nagao, Yoshihiro Yoshihara, Kensaku Mori

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

To examine the manner of interactions between immune cells and central nervous system (CNS) neurons, mouse hippocampal neurons were co-cultured with lymphokine (IL-2)-activated killer (LAK) cells. Immunocytochemical and time-lapse observations indicated that LAK cells migrated along neuronal processes and made adhesive contacts with them. In addition to the direct physical effects, LAK cells released glutamate, induced the formation of beads-like structure in the dendrites of about 14% of hippocampal neurons and caused the reduction of dendritic protrusions. These results suggest that infiltrating immune cells can form direct adhesive connections with CNS neurons and affect their dendritic morphology.

Original languageEnglish (US)
Pages (from-to)126-136
Number of pages11
JournalJournal of Neuroimmunology
Volume151
Issue number1-2
DOIs
StatePublished - Jun 1 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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