Activation of thin-fiber muscle afferents by a P2X agonist in cats

Ramy L. Hanna, Marc Kaufman

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The responses of group III and IV triceps surae muscle afferents to intra-arterial injection of α,β-methylene ATP (50 μg/kg) was examined in decerebrate cats. We found that this P2X3 agonist stimulated only three of 18 group III afferents but 7 of 9 group IV afferents (P < 0.004). The three group III afferents stimulated by α,β -methylene ATP conducted impulses below 4 m/s. Pyridoxal phosphate-6-azophenyl-2′,4′-disulfonic acid, a P2-receptor antagonist, prevented the stimulation of these afferents by α,β -methylene ATP. We conclude that P2X3 agonists stimulate only the slowest conducting group III muscle afferents as well as group IV afferents.

Original languageEnglish (US)
Pages (from-to)1166-1169
Number of pages4
JournalJournal of Applied Physiology
Volume96
Issue number3
DOIs
StatePublished - Mar 1 2004

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Cats
Adenosine Triphosphate
Muscles
Intra-Arterial Injections
Pyridoxal Phosphate
Acids

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

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abstract = "The responses of group III and IV triceps surae muscle afferents to intra-arterial injection of α,β-methylene ATP (50 μg/kg) was examined in decerebrate cats. We found that this P2X3 agonist stimulated only three of 18 group III afferents but 7 of 9 group IV afferents (P < 0.004). The three group III afferents stimulated by α,β -methylene ATP conducted impulses below 4 m/s. Pyridoxal phosphate-6-azophenyl-2′,4′-disulfonic acid, a P2-receptor antagonist, prevented the stimulation of these afferents by α,β -methylene ATP. We conclude that P2X3 agonists stimulate only the slowest conducting group III muscle afferents as well as group IV afferents.",
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Activation of thin-fiber muscle afferents by a P2X agonist in cats. / Hanna, Ramy L.; Kaufman, Marc.

In: Journal of Applied Physiology, Vol. 96, No. 3, 01.03.2004, p. 1166-1169.

Research output: Contribution to journalArticle

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