TY - JOUR
T1 - Active and latent forms of transforming growth factor β activity in synovial effusions
AU - Fava, R.
AU - Olsen, N.
AU - Keski-Oja, J.
AU - Moses, H.
AU - Pincus, T.
PY - 1989
Y1 - 1989
N2 - We have evaluated the possible involvement of TGF-β in rheumatoid arhritis by assay of 16 cell-free synovial fluids for the presence of its active and 'latent forms'. Evidence has been obtained for TGF-β-like activity in synovial effusions by four criteria: (a) TGF-β receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.
AB - We have evaluated the possible involvement of TGF-β in rheumatoid arhritis by assay of 16 cell-free synovial fluids for the presence of its active and 'latent forms'. Evidence has been obtained for TGF-β-like activity in synovial effusions by four criteria: (a) TGF-β receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.
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U2 - 10.1084/jem.169.1.291
DO - 10.1084/jem.169.1.291
M3 - Article
C2 - 2909658
AN - SCOPUS:0024541065
SN - 0022-1007
VL - 169
SP - 291
EP - 296
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 1
ER -