Active and latent forms of transforming growth factor β activity in synovial effusions

R. Fava, N. Olsen, J. Keski-Oja, H. Moses, T. Pincus

Research output: Contribution to journalArticle

202 Scopus citations

Abstract

We have evaluated the possible involvement of TGF-β in rheumatoid arhritis by assay of 16 cell-free synovial fluids for the presence of its active and 'latent forms'. Evidence has been obtained for TGF-β-like activity in synovial effusions by four criteria: (a) TGF-β receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalJournal of Experimental Medicine
Volume169
Issue number1
DOIs
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Active and latent forms of transforming growth factor β activity in synovial effusions'. Together they form a unique fingerprint.

  • Cite this