"Active" refuges can inhibit the evolution of resistance in insects towards transgenic insect-resistant plants

Barry R. Pittendrigh, Patrick J. Gaffney, Joseph E. Huesing, David W. Onstad, Richard T. Roush, Larry L. Murdock

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Negative cross-resistance (NCR) toxins that hitherto have not been thought to have practical uses may indeed be useful in the management of resistance alleles. Practical applications of NCR for pest management have been limited (i) by the scarcity of high toxicity NCR toxins among pesticides, (ii) by the lack of systematic methodologies to discover and develop such toxins, as well as (iii) by the lack of deployment tactics that would make NCR attractive. Here we present the concept that NCR toxins can improve the effectiveness of refuges in delaying the evolution of resistance by herbivorous insect pests to transgenic host plants containing insecticidal toxins. In our concept, NCR toxins are deployed in the refuge, and thus are physically separated from the transgenic plants containing the primary plant-protectant gene (PPPG) encoding an insecticidal toxin. Our models show: (i) that use of NCR toxins in the refuge dramatically delays the increase in the frequency of resistance alleles in the insect population; and (ii) that NCR toxins that are only moderately effective in killing insects resistant to the PPPG can greatly improve the durability of transgenic insecticidal toxins. Moderately toxic NCR toxins are more effective in minimizing resistance development in the field when they are deployed in the refuge than when they are pyramided with the PPPG. We explore the potential strengths and weaknesses of deploying NCR toxins in refuges.

Original languageEnglish (US)
Pages (from-to)461-474
Number of pages14
JournalJournal of Theoretical Biology
Volume231
Issue number4
DOIs
StatePublished - Dec 21 2004

Fingerprint

transgenic insects
Plant Genes
cross resistance
Insects
toxins
Genes
Genetically Modified Plants
insects
Gene encoding
Poisons
Pesticides
Toxicity
Pest Control
Durability
Gene Frequency
Alleles
Population
Resistance
Gene
transgenic plants

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Pittendrigh, Barry R. ; Gaffney, Patrick J. ; Huesing, Joseph E. ; Onstad, David W. ; Roush, Richard T. ; Murdock, Larry L. / "Active" refuges can inhibit the evolution of resistance in insects towards transgenic insect-resistant plants. In: Journal of Theoretical Biology. 2004 ; Vol. 231, No. 4. pp. 461-474.
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"Active" refuges can inhibit the evolution of resistance in insects towards transgenic insect-resistant plants. / Pittendrigh, Barry R.; Gaffney, Patrick J.; Huesing, Joseph E.; Onstad, David W.; Roush, Richard T.; Murdock, Larry L.

In: Journal of Theoretical Biology, Vol. 231, No. 4, 21.12.2004, p. 461-474.

Research output: Contribution to journalArticle

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