Acute adverse effects of fine particulate air pollution on ventricular repolarization

Duanping Liao, Michele L. Shaffer, Sol Rodriguez-Colon, Fan He, Xian Li, Deborah Wolbrette, Jeffrey Yanosky, Wayne E. Cascio

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

BACKGROUND: The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. OBJECTIVE: We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM 2.5 ) on ventricular repolarization of 106 nonsmoking adults who were living in communities in central Pennsylvania. METHODS: The 24-hr beat-to-beat electrocardiogram (ECG) data were obtained using a high-resolution 12-lead Holter system. After visually identifying and removing artifacts and arrhythmic beats, we summarized normal beat-to-beat QTs from each 30-min segment as heart rate (HR)-corrected QT measures: QT prolongation index (QTI), Bazett's HR-corrected QT (QTcB), and Fridericia's HR-corrected QT (QTcF). A personal PM 2.5 monitor was used to measure individual-level real-time PM 2.5 exposures for 24 hr. We averaged these data and used 30-min time-specific average PM 2.5 exposures. RESULTS: The mean age of the participants was 56 ± 8 years, with 41% male and 74% white. The means ± SDs for QTI, QTcB, and QTcF were 111 ± 6.6, 438 ± 23 msec, and 422 ± 22 msec, respectively; and for PM 2.5 , the mean ± SD was 14 ± 22 μg/m 3 . We used distributed lag models under a framework of linear mixed-effects models to assess the autocorrelation-corrected regression coefficients between (β) between 30-min PM 2.5 and the HR-corrected QT measures. Most of the adverse ventricular repolarization effects from PM 2.5 exposure occurred within 3-4 hr. The multivariable adjusted β(SE, p-value) due to a 10-μg/m 3 increase in lag 7 PM 2.5 on QTI, QTcB, and QTcF were 0.08 (0.04, p < 0.05), 0.22 (0.08, p < 0.01), and 0.09 (0.05, p < 0.05), respectively. CONCLUSIONS: Our results suggest a significant adverse effect of PM 2.5 on ventricular repolarization. The time course of the effect is within 3-4 hr of elevated PM 2.5 .

Original languageEnglish (US)
Pages (from-to)1010-1015
Number of pages6
JournalEnvironmental health perspectives
Volume118
Issue number7
DOIs
StatePublished - Jan 1 2010

Fingerprint

Air Pollution
Heart Rate
Particulate Matter
Artifacts
Heart Diseases
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Liao, Duanping ; Shaffer, Michele L. ; Rodriguez-Colon, Sol ; He, Fan ; Li, Xian ; Wolbrette, Deborah ; Yanosky, Jeffrey ; Cascio, Wayne E. / Acute adverse effects of fine particulate air pollution on ventricular repolarization. In: Environmental health perspectives. 2010 ; Vol. 118, No. 7. pp. 1010-1015.
@article{4b7078e5b3f741a49f49abbfdd1428ac,
title = "Acute adverse effects of fine particulate air pollution on ventricular repolarization",
abstract = "BACKGROUND: The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. OBJECTIVE: We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM 2.5 ) on ventricular repolarization of 106 nonsmoking adults who were living in communities in central Pennsylvania. METHODS: The 24-hr beat-to-beat electrocardiogram (ECG) data were obtained using a high-resolution 12-lead Holter system. After visually identifying and removing artifacts and arrhythmic beats, we summarized normal beat-to-beat QTs from each 30-min segment as heart rate (HR)-corrected QT measures: QT prolongation index (QTI), Bazett's HR-corrected QT (QTcB), and Fridericia's HR-corrected QT (QTcF). A personal PM 2.5 monitor was used to measure individual-level real-time PM 2.5 exposures for 24 hr. We averaged these data and used 30-min time-specific average PM 2.5 exposures. RESULTS: The mean age of the participants was 56 ± 8 years, with 41{\%} male and 74{\%} white. The means ± SDs for QTI, QTcB, and QTcF were 111 ± 6.6, 438 ± 23 msec, and 422 ± 22 msec, respectively; and for PM 2.5 , the mean ± SD was 14 ± 22 μg/m 3 . We used distributed lag models under a framework of linear mixed-effects models to assess the autocorrelation-corrected regression coefficients between (β) between 30-min PM 2.5 and the HR-corrected QT measures. Most of the adverse ventricular repolarization effects from PM 2.5 exposure occurred within 3-4 hr. The multivariable adjusted β(SE, p-value) due to a 10-μg/m 3 increase in lag 7 PM 2.5 on QTI, QTcB, and QTcF were 0.08 (0.04, p < 0.05), 0.22 (0.08, p < 0.01), and 0.09 (0.05, p < 0.05), respectively. CONCLUSIONS: Our results suggest a significant adverse effect of PM 2.5 on ventricular repolarization. The time course of the effect is within 3-4 hr of elevated PM 2.5 .",
author = "Duanping Liao and Shaffer, {Michele L.} and Sol Rodriguez-Colon and Fan He and Xian Li and Deborah Wolbrette and Jeffrey Yanosky and Cascio, {Wayne E.}",
year = "2010",
month = "1",
day = "1",
doi = "10.1289/ehp.0901648",
language = "English (US)",
volume = "118",
pages = "1010--1015",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "7",

}

Acute adverse effects of fine particulate air pollution on ventricular repolarization. / Liao, Duanping; Shaffer, Michele L.; Rodriguez-Colon, Sol; He, Fan; Li, Xian; Wolbrette, Deborah; Yanosky, Jeffrey; Cascio, Wayne E.

In: Environmental health perspectives, Vol. 118, No. 7, 01.01.2010, p. 1010-1015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acute adverse effects of fine particulate air pollution on ventricular repolarization

AU - Liao, Duanping

AU - Shaffer, Michele L.

AU - Rodriguez-Colon, Sol

AU - He, Fan

AU - Li, Xian

AU - Wolbrette, Deborah

AU - Yanosky, Jeffrey

AU - Cascio, Wayne E.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - BACKGROUND: The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. OBJECTIVE: We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM 2.5 ) on ventricular repolarization of 106 nonsmoking adults who were living in communities in central Pennsylvania. METHODS: The 24-hr beat-to-beat electrocardiogram (ECG) data were obtained using a high-resolution 12-lead Holter system. After visually identifying and removing artifacts and arrhythmic beats, we summarized normal beat-to-beat QTs from each 30-min segment as heart rate (HR)-corrected QT measures: QT prolongation index (QTI), Bazett's HR-corrected QT (QTcB), and Fridericia's HR-corrected QT (QTcF). A personal PM 2.5 monitor was used to measure individual-level real-time PM 2.5 exposures for 24 hr. We averaged these data and used 30-min time-specific average PM 2.5 exposures. RESULTS: The mean age of the participants was 56 ± 8 years, with 41% male and 74% white. The means ± SDs for QTI, QTcB, and QTcF were 111 ± 6.6, 438 ± 23 msec, and 422 ± 22 msec, respectively; and for PM 2.5 , the mean ± SD was 14 ± 22 μg/m 3 . We used distributed lag models under a framework of linear mixed-effects models to assess the autocorrelation-corrected regression coefficients between (β) between 30-min PM 2.5 and the HR-corrected QT measures. Most of the adverse ventricular repolarization effects from PM 2.5 exposure occurred within 3-4 hr. The multivariable adjusted β(SE, p-value) due to a 10-μg/m 3 increase in lag 7 PM 2.5 on QTI, QTcB, and QTcF were 0.08 (0.04, p < 0.05), 0.22 (0.08, p < 0.01), and 0.09 (0.05, p < 0.05), respectively. CONCLUSIONS: Our results suggest a significant adverse effect of PM 2.5 on ventricular repolarization. The time course of the effect is within 3-4 hr of elevated PM 2.5 .

AB - BACKGROUND: The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. OBJECTIVE: We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM 2.5 ) on ventricular repolarization of 106 nonsmoking adults who were living in communities in central Pennsylvania. METHODS: The 24-hr beat-to-beat electrocardiogram (ECG) data were obtained using a high-resolution 12-lead Holter system. After visually identifying and removing artifacts and arrhythmic beats, we summarized normal beat-to-beat QTs from each 30-min segment as heart rate (HR)-corrected QT measures: QT prolongation index (QTI), Bazett's HR-corrected QT (QTcB), and Fridericia's HR-corrected QT (QTcF). A personal PM 2.5 monitor was used to measure individual-level real-time PM 2.5 exposures for 24 hr. We averaged these data and used 30-min time-specific average PM 2.5 exposures. RESULTS: The mean age of the participants was 56 ± 8 years, with 41% male and 74% white. The means ± SDs for QTI, QTcB, and QTcF were 111 ± 6.6, 438 ± 23 msec, and 422 ± 22 msec, respectively; and for PM 2.5 , the mean ± SD was 14 ± 22 μg/m 3 . We used distributed lag models under a framework of linear mixed-effects models to assess the autocorrelation-corrected regression coefficients between (β) between 30-min PM 2.5 and the HR-corrected QT measures. Most of the adverse ventricular repolarization effects from PM 2.5 exposure occurred within 3-4 hr. The multivariable adjusted β(SE, p-value) due to a 10-μg/m 3 increase in lag 7 PM 2.5 on QTI, QTcB, and QTcF were 0.08 (0.04, p < 0.05), 0.22 (0.08, p < 0.01), and 0.09 (0.05, p < 0.05), respectively. CONCLUSIONS: Our results suggest a significant adverse effect of PM 2.5 on ventricular repolarization. The time course of the effect is within 3-4 hr of elevated PM 2.5 .

UR - http://www.scopus.com/inward/record.url?scp=77954839998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954839998&partnerID=8YFLogxK

U2 - 10.1289/ehp.0901648

DO - 10.1289/ehp.0901648

M3 - Article

C2 - 20363686

AN - SCOPUS:77954839998

VL - 118

SP - 1010

EP - 1015

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 7

ER -