Acute effects of arterio-venous shunt on cardiovascular hemodynamics in rat

Stephen F. Flaim, William J. Minteer, Robert Zelis

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The cardiovascular effects of an acute high cardiac output state (Acute HCO) were determined in rats 24 h after opening an abdominal aorta-caval shunt equal to 50% of total cardiac output (CO). Heart rate (HR), left ventricular peak (LVP), end diastolic (LVEDP), and arterial (AP) pressures, CO, stroke volume (SV), total systemic and regional vascular resistance (VR), regional blood flow (BF) (radioactive microspheres), and tissue fluid content data were collected. In Acute HCO, AP and LVP were reduced while LVEDP was elevated, total CO was increased and total VR was decreased while systemic CO and VR were unchanged. In Acute HCO, HR did not change significantly and SV was significantly increased. Lung water in Acute HCO was significantly greater than control. Regional BF changes in Acute HCO include skeletal muscle reflex vasoconstriction and splanchnic and cerebral dilation. The results in conjunction with previous data on chronic HCO indicate that in the rat (1) increased lung water which is absent after cardiovascular compensation is an acute result of HCO, and (2) the acute phase of cardiac compensation to HCO occurs in the absence of a tachycardia response.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalPflügers Archiv European Journal of Physiology
Volume385
Issue number3
DOIs
StatePublished - Jun 1 1980

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High Cardiac Output
Hemodynamics
Rats
Blood
Cardiac Output
Water
Vascular Resistance
Microspheres
Regional Blood Flow
Muscle
Stroke Volume
Tissue
Heart Rate
Fluids
Lung
Venae Cavae
Viscera
Abdominal Aorta
Vasoconstriction
Tachycardia

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

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Acute effects of arterio-venous shunt on cardiovascular hemodynamics in rat. / Flaim, Stephen F.; Minteer, William J.; Zelis, Robert.

In: Pflügers Archiv European Journal of Physiology, Vol. 385, No. 3, 01.06.1980, p. 203-209.

Research output: Contribution to journalArticle

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