(1) Two detoxified male heroin addicts were given 10 mg of intravenous heroin and experienced a rapid fall in plasma LH. FSH levels were unchanged. (2) Approximately 4 hr after LH suppression (by heroin), plasma testosterone levels also dropped markedly. (3) Naltrexone pretreatment prevented opiate-induced suppression of both LH and testosterone. (4) Instead, an increased number of secretory bursts of LH occurred after naltrexone administration, and mean plasma LH levels were higher than those obtained during a saline control period. (5) Testosterone and FSH secretion were not appreciably affected by naltrexone treatment.
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
- Psychiatry and Mental health
- Biological Psychiatry