Acute effects of heroin and naltrexone on testosterone and gonadotropin secretion: A pilot study

Steven M. Mirin, Jack H. Mendelson, James Ellingboe, Roger E. Meyer

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

(1) Two detoxified male heroin addicts were given 10 mg of intravenous heroin and experienced a rapid fall in plasma LH. FSH levels were unchanged. (2) Approximately 4 hr after LH suppression (by heroin), plasma testosterone levels also dropped markedly. (3) Naltrexone pretreatment prevented opiate-induced suppression of both LH and testosterone. (4) Instead, an increased number of secretory bursts of LH occurred after naltrexone administration, and mean plasma LH levels were higher than those obtained during a saline control period. (5) Testosterone and FSH secretion were not appreciably affected by naltrexone treatment.

Original languageEnglish (US)
Pages (from-to)359-369
Number of pages11
JournalPsychoneuroendocrinology
Volume1
Issue number4
DOIs
StatePublished - 1976

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

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