Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac function

Steven C. Koenig, Kenneth N. Litwak, Guruprasad A. Giridharan, George M. Pantalos, Robert Dowling, Sumanth D. Prabhu, Mark S. Slaughter, Michael A. Sobieski, Paul A. Spence

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The acute hemodynamic efficacy of an implantable counterpulsation device (CPD) was evaluated. The CPD is a valveless single port, 32-ml stroke volume blood chamber designed to be connected to the human axillary artery using a simple surface surgical procedure. Blood is drawn into the pump during systole and ejected during diastole. The acute hemodynamic effects of the 32-ml CPD were compared to a standard clinical 40-ml intra-aortic balloon pump (IABP) in calves (80 kg, n = 10). The calves were treated by a single oral dose of Monensin to produce a model of diminished cardiac function (DCF). The CPD and IABP produced similar increases in cardiac output (6% CPD vs. 5% IABP, p > 0.5) and reduction in left ventricular external work (14% CPD vs. 13% IABP, p > 0.5) compared to DCF (p < 0.05). However, the ratio of diastolic coronary artery flow to left ventricular external work increase from DCF baseline (p < 0.05) was greater with the CPD compared to the IABP (15% vs. 4%, p < 0.05). The CPD also produced a greater reduction in left ventricular myocardial oxygen consumption from DCF baseline (p < 0.05) compared to the IABP (13% vs. 9%, p < 0.05) despite each device providing similar improvements in cardiac output. There was no early indication of hemolysis, thrombus formation, or vascular injury. The CPD provides hemodynamic efficacy equivalent to an IABP and may become a therapeutic option for patients who may benefit from prolonged counterpulsation.

Original languageEnglish (US)
Pages (from-to)578-584
Number of pages7
JournalASAIO Journal
Volume54
Issue number6
DOIs
StatePublished - Nov 1 2008

Fingerprint

Counterpulsation
Hemodynamics
Balloons
Pumps
Equipment and Supplies
Blood
Cardiac Output
Monensin
Axillary Artery
Diastole
Systole
Vascular System Injuries
Hemolysis
Oxygen Consumption
Stroke Volume
Oxygen
Coronary Vessels
Thrombosis

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biophysics
  • Medicine(all)
  • Biomaterials
  • Biomedical Engineering

Cite this

Koenig, Steven C. ; Litwak, Kenneth N. ; Giridharan, Guruprasad A. ; Pantalos, George M. ; Dowling, Robert ; Prabhu, Sumanth D. ; Slaughter, Mark S. ; Sobieski, Michael A. ; Spence, Paul A. / Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac function. In: ASAIO Journal. 2008 ; Vol. 54, No. 6. pp. 578-584.
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abstract = "The acute hemodynamic efficacy of an implantable counterpulsation device (CPD) was evaluated. The CPD is a valveless single port, 32-ml stroke volume blood chamber designed to be connected to the human axillary artery using a simple surface surgical procedure. Blood is drawn into the pump during systole and ejected during diastole. The acute hemodynamic effects of the 32-ml CPD were compared to a standard clinical 40-ml intra-aortic balloon pump (IABP) in calves (80 kg, n = 10). The calves were treated by a single oral dose of Monensin to produce a model of diminished cardiac function (DCF). The CPD and IABP produced similar increases in cardiac output (6{\%} CPD vs. 5{\%} IABP, p > 0.5) and reduction in left ventricular external work (14{\%} CPD vs. 13{\%} IABP, p > 0.5) compared to DCF (p < 0.05). However, the ratio of diastolic coronary artery flow to left ventricular external work increase from DCF baseline (p < 0.05) was greater with the CPD compared to the IABP (15{\%} vs. 4{\%}, p < 0.05). The CPD also produced a greater reduction in left ventricular myocardial oxygen consumption from DCF baseline (p < 0.05) compared to the IABP (13{\%} vs. 9{\%}, p < 0.05) despite each device providing similar improvements in cardiac output. There was no early indication of hemolysis, thrombus formation, or vascular injury. The CPD provides hemodynamic efficacy equivalent to an IABP and may become a therapeutic option for patients who may benefit from prolonged counterpulsation.",
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Koenig, SC, Litwak, KN, Giridharan, GA, Pantalos, GM, Dowling, R, Prabhu, SD, Slaughter, MS, Sobieski, MA & Spence, PA 2008, 'Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac function', ASAIO Journal, vol. 54, no. 6, pp. 578-584. https://doi.org/10.1097/MAT.0b013e318186891f

Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac function. / Koenig, Steven C.; Litwak, Kenneth N.; Giridharan, Guruprasad A.; Pantalos, George M.; Dowling, Robert; Prabhu, Sumanth D.; Slaughter, Mark S.; Sobieski, Michael A.; Spence, Paul A.

In: ASAIO Journal, Vol. 54, No. 6, 01.11.2008, p. 578-584.

Research output: Contribution to journalArticle

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AU - Koenig, Steven C.

AU - Litwak, Kenneth N.

AU - Giridharan, Guruprasad A.

AU - Pantalos, George M.

AU - Dowling, Robert

AU - Prabhu, Sumanth D.

AU - Slaughter, Mark S.

AU - Sobieski, Michael A.

AU - Spence, Paul A.

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N2 - The acute hemodynamic efficacy of an implantable counterpulsation device (CPD) was evaluated. The CPD is a valveless single port, 32-ml stroke volume blood chamber designed to be connected to the human axillary artery using a simple surface surgical procedure. Blood is drawn into the pump during systole and ejected during diastole. The acute hemodynamic effects of the 32-ml CPD were compared to a standard clinical 40-ml intra-aortic balloon pump (IABP) in calves (80 kg, n = 10). The calves were treated by a single oral dose of Monensin to produce a model of diminished cardiac function (DCF). The CPD and IABP produced similar increases in cardiac output (6% CPD vs. 5% IABP, p > 0.5) and reduction in left ventricular external work (14% CPD vs. 13% IABP, p > 0.5) compared to DCF (p < 0.05). However, the ratio of diastolic coronary artery flow to left ventricular external work increase from DCF baseline (p < 0.05) was greater with the CPD compared to the IABP (15% vs. 4%, p < 0.05). The CPD also produced a greater reduction in left ventricular myocardial oxygen consumption from DCF baseline (p < 0.05) compared to the IABP (13% vs. 9%, p < 0.05) despite each device providing similar improvements in cardiac output. There was no early indication of hemolysis, thrombus formation, or vascular injury. The CPD provides hemodynamic efficacy equivalent to an IABP and may become a therapeutic option for patients who may benefit from prolonged counterpulsation.

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