Adaptive Trials in Cardiology: Some Considerations and Examples

John Mandrola, Andrew D. Althouse, Andrew Foy, Deepak L. Bhatt

Research output: Contribution to journalReview articlepeer-review

Abstract

Adaptive trials hold great promise to enhance the evidence base supporting medical interventions. In this review, we will describe the basic principles of an adaptive trial and the different types of adaptive trials, show examples of adaptive trials, and conclude with the advantages and challenges of different types of adaptive trials. While regulatory bodies have expressed a desire to see more adaptive trials, resistance in the community remains. We hope that this review helps to build greater acceptance of the concept of adaptive trial design.

Original languageEnglish (US)
Pages (from-to)1428-1437
Number of pages10
JournalCanadian Journal of Cardiology
Volume37
Issue number9
DOIs
StatePublished - Sep 2021

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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