Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)—From trajectories to mechanisms and interventions

Andreas Heinz, Falk Kiefer, Michael N. Smolka, Tanja Endrass, Christian Beste, Anne Beck, Shuyan Liu, Alexander Genauck, Lydia Romund, Tobias Banaschewski, Felix Bermpohl, Lorenz Deserno, Raymond J. Dolan, Daniel Durstewitz, Ulrich Ebner-Priemer, Herta Flor, Anita C. Hansson, Christine Heim, Derik Hermann, Stefan KiebelPeter Kirsch, Clemens Kirschbaum, Georgia Koppe, Michael Marxen, Andreas Meyer-Lindenberg, Wolfgang E. Nagel, Hamid R. Noori, Maximilian Pilhatsch, Josef Priller, Marcella Rietschel, Nina Romanczuk-Seiferth, Florian Schlagenhauf, Wolfgang H. Sommer, Jan Stallkamp, Andreas Ströhle, Ann Kathrin Stock, Georg Winterer, Christine Winter, Henrik Walter, Stephanie Witt, Sabine Vollstädt-Klein, Michael A. Rapp, Heike Tost, Rainer Spanagel

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.

Original languageEnglish (US)
Article numbere12866
JournalAddiction Biology
Volume25
Issue number2
DOIs
StatePublished - Mar 1 2020

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

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