Addition of doxycycline to ciprofloxacin for infection prophylaxis during autologous stem cell transplants for multiple myeloma

J. M. Sivik, J. Davidson, C. M. Hale, Joseph Drabick, Giampaolo Talamo

Research output: Contribution to journalArticle

Abstract

Background: The most commonly used antibacterial prophylaxis during autologous stem cell transplants (ASCT) for multiple myeloma (MM) involves a fluoroquinolone, such as ciprofloxacin or levofloxacin. We assessed the impact of adding doxycycline to ciprofloxacin as routine antibacterial prophylaxis in these patients. Methods: We retrospectively reviewed electronic medical records and our ASCT database to analyze rates and types of bacterial infections in MM patients who underwent ASCT in our institution. Results: Among 419 patients, 118 received ciprofloxacin alone (cipro group), and 301 ciprofloxacin and doxycycline (cipro-doxy group). Neutropenic fever (NF) developed in 63 (53%) and 108 (36%) patients of the cipro and cipro-doxy groups, respectively (p = 0.010). The number of documented bacteremic episodes was 13 (11%) and 14 (4.7%) in the two groups, respectively (p = 0.017). Antimicrobial resistance and Clostridium difficile infections were uncommon. Transplant-related mortality was 1% in both groups. Conclusions: The addition of doxycycline to standard prophylaxis with ciprofloxacin seems to reduce the number of NF episodes and documented bacterial infections in patients with MM undergoing ASCT, without increasing rate of serious complications.

Original languageEnglish (US)
Pages (from-to)3055-3061
Number of pages7
JournalSupportive Care in Cancer
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2018

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Doxycycline
Ciprofloxacin
Multiple Myeloma
Stem Cells
Transplants
Infection
Bacterial Infections
Fever
Clostridium Infections
Levofloxacin
Clostridium difficile
Electronic Health Records
Fluoroquinolones
Databases
Mortality

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

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title = "Addition of doxycycline to ciprofloxacin for infection prophylaxis during autologous stem cell transplants for multiple myeloma",
abstract = "Background: The most commonly used antibacterial prophylaxis during autologous stem cell transplants (ASCT) for multiple myeloma (MM) involves a fluoroquinolone, such as ciprofloxacin or levofloxacin. We assessed the impact of adding doxycycline to ciprofloxacin as routine antibacterial prophylaxis in these patients. Methods: We retrospectively reviewed electronic medical records and our ASCT database to analyze rates and types of bacterial infections in MM patients who underwent ASCT in our institution. Results: Among 419 patients, 118 received ciprofloxacin alone (cipro group), and 301 ciprofloxacin and doxycycline (cipro-doxy group). Neutropenic fever (NF) developed in 63 (53{\%}) and 108 (36{\%}) patients of the cipro and cipro-doxy groups, respectively (p = 0.010). The number of documented bacteremic episodes was 13 (11{\%}) and 14 (4.7{\%}) in the two groups, respectively (p = 0.017). Antimicrobial resistance and Clostridium difficile infections were uncommon. Transplant-related mortality was 1{\%} in both groups. Conclusions: The addition of doxycycline to standard prophylaxis with ciprofloxacin seems to reduce the number of NF episodes and documented bacterial infections in patients with MM undergoing ASCT, without increasing rate of serious complications.",
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Addition of doxycycline to ciprofloxacin for infection prophylaxis during autologous stem cell transplants for multiple myeloma. / Sivik, J. M.; Davidson, J.; Hale, C. M.; Drabick, Joseph; Talamo, Giampaolo.

In: Supportive Care in Cancer, Vol. 26, No. 9, 01.09.2018, p. 3055-3061.

Research output: Contribution to journalArticle

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T1 - Addition of doxycycline to ciprofloxacin for infection prophylaxis during autologous stem cell transplants for multiple myeloma

AU - Sivik, J. M.

AU - Davidson, J.

AU - Hale, C. M.

AU - Drabick, Joseph

AU - Talamo, Giampaolo

PY - 2018/9/1

Y1 - 2018/9/1

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