Addition of Grignard and Organolithium Reagents to N-Sulfonyl Aldimines Generated in Situ from Aldehydes and N-Sulfinyl Sulfonamides

Joseph Sisko, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

The addition of organometallic reagents to imines is often a poor synthetic reaction due to competing processes such as a-deprotonation and reductive dimerization. Alkyl and aryl Grignard and organolithium species have proven particularly troublesome, although some useful solutions to the problem have recently been presented1-4.

Original languageEnglish (US)
Pages (from-to)393-395
Number of pages3
JournalJournal of Organic Chemistry
Volume55
Issue number1
DOIs
StatePublished - Jan 1 1990

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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