Addition of Grignard and Organolithium Reagents to N-Sulfonyl Aldimines Generated in Situ from Aldehydes and N-Sulfinyl Sulfonamides

Joseph Sisko, Steven M. Weinreb

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The addition of organometallic reagents to imines is often a poor synthetic reaction due to competing processes such as a-deprotonation and reductive dimerization. Alkyl and aryl Grignard and organolithium species have proven particularly troublesome, although some useful solutions to the problem have recently been presented1-4.

Original languageEnglish (US)
Pages (from-to)393-395
Number of pages3
JournalJournal of Organic Chemistry
Volume55
Issue number1
DOIs
StatePublished - Jan 1 1990

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Deprotonation
Imines
Dimerization
Sulfonamides
Organometallics
Aldehydes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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abstract = "The addition of organometallic reagents to imines is often a poor synthetic reaction due to competing processes such as a-deprotonation and reductive dimerization. Alkyl and aryl Grignard and organolithium species have proven particularly troublesome, although some useful solutions to the problem have recently been presented1-4.",
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Addition of Grignard and Organolithium Reagents to N-Sulfonyl Aldimines Generated in Situ from Aldehydes and N-Sulfinyl Sulfonamides. / Sisko, Joseph; Weinreb, Steven M.

In: Journal of Organic Chemistry, Vol. 55, No. 1, 01.01.1990, p. 393-395.

Research output: Contribution to journalArticle

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