Additions and Corrections: Stereoselective Chemical Reduction of 5,10-Methenyltetrahydrofolate. (Journal of the American Chemical Society (1973) 95(16) (5409–5411)(10.1021/ja00797a050))

Peter R. Farina, Linda J. Farina, Stephen Benkovic

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Abstract

The assignment in Figure 1 to the methylene bridge protons of 5,10-methylenetetrahydrofolate is incomplete. The depicted doublet at 4.94 ppm is only one-half of an AX quartet; the remaining half is centered at 3.75 ppm. Instability in the field frequency lock and masking by solvent contributed to the misassignment. The stereochemical preference for one diastereomer in the system illustrated is about 60-70%.

Original languageEnglish (US)
Number of pages1
JournalJournal of the American Chemical Society
Volume97
Issue number14
DOIs
StatePublished - Jul 1 1975

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Protons
5,10-methenyltetrahydrofolate
5,10-methylenetetrahydrofolic acid

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

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title = "Additions and Corrections: Stereoselective Chemical Reduction of 5,10-Methenyltetrahydrofolate. (Journal of the American Chemical Society (1973) 95(16) (5409–5411)(10.1021/ja00797a050))",
abstract = "The assignment in Figure 1 to the methylene bridge protons of 5,10-methylenetetrahydrofolate is incomplete. The depicted doublet at 4.94 ppm is only one-half of an AX quartet; the remaining half is centered at 3.75 ppm. Instability in the field frequency lock and masking by solvent contributed to the misassignment. The stereochemical preference for one diastereomer in the system illustrated is about 60-70{\%}.",
author = "Farina, {Peter R.} and Farina, {Linda J.} and Stephen Benkovic",
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language = "English (US)",
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T1 - Additions and Corrections

T2 - Stereoselective Chemical Reduction of 5,10-Methenyltetrahydrofolate. (Journal of the American Chemical Society (1973) 95(16) (5409–5411)(10.1021/ja00797a050))

AU - Farina, Peter R.

AU - Farina, Linda J.

AU - Benkovic, Stephen

PY - 1975/7/1

Y1 - 1975/7/1

N2 - The assignment in Figure 1 to the methylene bridge protons of 5,10-methylenetetrahydrofolate is incomplete. The depicted doublet at 4.94 ppm is only one-half of an AX quartet; the remaining half is centered at 3.75 ppm. Instability in the field frequency lock and masking by solvent contributed to the misassignment. The stereochemical preference for one diastereomer in the system illustrated is about 60-70%.

AB - The assignment in Figure 1 to the methylene bridge protons of 5,10-methylenetetrahydrofolate is incomplete. The depicted doublet at 4.94 ppm is only one-half of an AX quartet; the remaining half is centered at 3.75 ppm. Instability in the field frequency lock and masking by solvent contributed to the misassignment. The stereochemical preference for one diastereomer in the system illustrated is about 60-70%.

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DO - 10.1021/ja00847a601

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VL - 97

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SN - 0002-7863

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