Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency

Carla M. Ward, Harumi Jyonouchi, Sergei V. Kotenko, Sergey V. Smirnov, Rakesh Patel, Helen Aguila, George McSherry, Barry Dashefsky, Steven M. Holland

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We report adjunct treatment of (interferon) IFN-α2b (Intron-A) in a patient with complete interferon-γ receptor R1 (IFNGR1) deficiency suffering from disseminated infection with Mycobacterium avium complex (MAC) resistant to multiple anti-mycobacterial agents. A low dose of IFN-α2b (3 × 106 units/m2 three times weekly subcutaneously) successfully attenuated progressive hepatosplenomegaly and abdominal/ retroperitoneal/pelvic lymphadenopathy, although the patient continued to be mycobacteremic. This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-α2b for disseminated MAC infection.

Original languageEnglish (US)
Pages (from-to)981-985
Number of pages5
JournalEuropean Journal of Pediatrics
Volume166
Issue number9
DOIs
StatePublished - Sep 1 2007

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interferon alfa-2b
Mycobacterium avium Complex
Interferon Receptors
Infection
Introns
Interferons
Anti-Bacterial Agents
Therapeutics
interferon gamma receptor

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Ward, Carla M. ; Jyonouchi, Harumi ; Kotenko, Sergei V. ; Smirnov, Sergey V. ; Patel, Rakesh ; Aguila, Helen ; McSherry, George ; Dashefsky, Barry ; Holland, Steven M. / Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. In: European Journal of Pediatrics. 2007 ; Vol. 166, No. 9. pp. 981-985.
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Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. / Ward, Carla M.; Jyonouchi, Harumi; Kotenko, Sergei V.; Smirnov, Sergey V.; Patel, Rakesh; Aguila, Helen; McSherry, George; Dashefsky, Barry; Holland, Steven M.

In: European Journal of Pediatrics, Vol. 166, No. 9, 01.09.2007, p. 981-985.

Research output: Contribution to journalArticle

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AU - Ward, Carla M.

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