Adjuvant chemotherapy for breast cancer: Effects on cerebral white matter seen in diffusion tensor imaging

Jame Abraham, Marc W. Haut, Maria T. Moran, Shannon Filburn, Susan Lemiuex, Hiroto Kuwabara

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to examine the effect of adjuvant chemotherapy on normal-appearing white matter in women with breast cancer. Patients and Methods: Ten patients with early-stage breast cancer who were treated with adjuvant chemotherapy and 9 age-, education-, and IQ-matched healthy controls were studied with magnetic resonance imaging. Diffusion tensor imaging was used to calculate fractional anisotropy (FA), a measure of white matter integrity. Measurements were made in the genu and splenium of the corpus callosum. Participants also completed measures of processing speed, depression, and anxiety. Results: Relative to controls, patients had slower processing speed and lower FA in the genu. Processing speed was positively correlated with FA in the genu. Conclusion: The results of this pilot study suggest that adjuvant chemotherapy affects normal-appearing white matter in the genu of the corpus callosum and that this is related to the cognitive deficits experienced by patients.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalClinical Breast Cancer
Volume8
Issue number1
DOIs
StatePublished - Feb 2008

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Diffusion Tensor Imaging
Adjuvant Chemotherapy
Anisotropy
Breast Neoplasms
Corpus Callosum
Anxiety
Magnetic Resonance Imaging
Depression
Education
White Matter

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Abraham, Jame ; Haut, Marc W. ; Moran, Maria T. ; Filburn, Shannon ; Lemiuex, Susan ; Kuwabara, Hiroto. / Adjuvant chemotherapy for breast cancer : Effects on cerebral white matter seen in diffusion tensor imaging. In: Clinical Breast Cancer. 2008 ; Vol. 8, No. 1. pp. 88-91.
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Adjuvant chemotherapy for breast cancer : Effects on cerebral white matter seen in diffusion tensor imaging. / Abraham, Jame; Haut, Marc W.; Moran, Maria T.; Filburn, Shannon; Lemiuex, Susan; Kuwabara, Hiroto.

In: Clinical Breast Cancer, Vol. 8, No. 1, 02.2008, p. 88-91.

Research output: Contribution to journalArticle

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T2 - Effects on cerebral white matter seen in diffusion tensor imaging

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