Adoptive cell transfer: Is it a promising immunotherapy for colorectal cancer?

Jiaqiao Fan, Dong Shang, Bing Han, Jianxun Song, Hailong Chen, Jin Ming Yang

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colorectal cancer (CRC) is among the most common malignancies and causes millions of deaths worldwide every year. In this review, we discuss the status and perspective of the ACT in the treatment of CRC.

Original languageEnglish (US)
Pages (from-to)5784-5800
Number of pages17
JournalTheranostics
Volume8
Issue number20
DOIs
StatePublished - 2018

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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