Adrenal androgens, sex-hormone binding globulin and bone density in osteoporotic menopausal women: is there a relationship?

Robert A. Wild, James R. Buchanan, Cathleen Myers, Thomas Lloyd, Laurence Demers

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The relationships among sex steroids, sex hormone binding globulin (SHBG) and vertebral bone density as measured by computerized tomography were studied in 18 post-menopausal women. A significant negative correlation was found between SHBG binding capacity (SHBG-BC) and bone density. Bone density and the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) declined with age, and SHBG-BC was correlated significantly with DHEAS concentrations. The relationship between SHBG-BC and bone density may be affected by adrenal androgen output.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalMaturitas
Volume9
Issue number1
DOIs
StatePublished - Apr 1987

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

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