Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium

Emanuele Leoncini, Walter Ricciardi, Gabriella Cadoni, Dario Arzani, Livia Petrelli, Gaetano Paludetti, Paul Brennan, Daniele Luce, Isabelle Stucker, Keitaro Matsuo, Renato Talamini, Carlo La Vecchia, Andrew F. Olshan, Deborah M. Winn, Rolando Herrero, Silvia Franceschi, Xavier Castellsague, Joshua Muscat, Hal Morgenstern, Zuo Feng ZhangFabio Levi, Luigino Dal Maso, Karl Kelsey, Michael McClean, Thomas L. Vaughan, Philip Lazarus, Mark P. Purdue, Richard B. Hayes, Chu Chen, Stephen M. Schwartz, Oxana Shangina, Sergio Koifman, Wolfgang Ahrens, Elena Matos, Pagona Lagiou, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Leticia Fernandez, Ana Menezes, Antonio Agudo, Alexander W. Daudt, Lorenzo Richiardi, Kristina Kjaerheim, Dana Mates, Jaroslav Betka, Guo Pei Yu, Stimson Schantz, Lorenzo Simonato, Hermann Brenner, David I. Conway, Tatiana V. Macfarlane, Peter Thomson, Eleonora Fabianova, Ariana Znaor, Peter Rudnai, Claire Healy, Paolo Boffetta, Shu Chun Chuang, Yuan Chin Amy Lee, Mia Hashibe, Stefania Boccia

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Original languageEnglish (US)
Pages (from-to)35-48
Number of pages14
JournalEuropean Journal of Epidemiology
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2014

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Head and Neck Neoplasms
Odds Ratio
Confidence Intervals
Smoking
Mouth Neoplasms
Tobacco Use
Pharynx
Energy Intake
Alcohol Drinking
Case-Control Studies
Epidemiologic Studies
Epidemiology
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Leoncini, E., Ricciardi, W., Cadoni, G., Arzani, D., Petrelli, L., Paludetti, G., ... Boccia, S. (2014). Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium. European Journal of Epidemiology, 29(1), 35-48. https://doi.org/10.1007/s10654-013-9863-2
Leoncini, Emanuele ; Ricciardi, Walter ; Cadoni, Gabriella ; Arzani, Dario ; Petrelli, Livia ; Paludetti, Gaetano ; Brennan, Paul ; Luce, Daniele ; Stucker, Isabelle ; Matsuo, Keitaro ; Talamini, Renato ; La Vecchia, Carlo ; Olshan, Andrew F. ; Winn, Deborah M. ; Herrero, Rolando ; Franceschi, Silvia ; Castellsague, Xavier ; Muscat, Joshua ; Morgenstern, Hal ; Zhang, Zuo Feng ; Levi, Fabio ; Dal Maso, Luigino ; Kelsey, Karl ; McClean, Michael ; Vaughan, Thomas L. ; Lazarus, Philip ; Purdue, Mark P. ; Hayes, Richard B. ; Chen, Chu ; Schwartz, Stephen M. ; Shangina, Oxana ; Koifman, Sergio ; Ahrens, Wolfgang ; Matos, Elena ; Lagiou, Pagona ; Lissowska, Jolanta ; Szeszenia-Dabrowska, Neonila ; Fernandez, Leticia ; Menezes, Ana ; Agudo, Antonio ; Daudt, Alexander W. ; Richiardi, Lorenzo ; Kjaerheim, Kristina ; Mates, Dana ; Betka, Jaroslav ; Yu, Guo Pei ; Schantz, Stimson ; Simonato, Lorenzo ; Brenner, Hermann ; Conway, David I. ; Macfarlane, Tatiana V. ; Thomson, Peter ; Fabianova, Eleonora ; Znaor, Ariana ; Rudnai, Peter ; Healy, Claire ; Boffetta, Paolo ; Chuang, Shu Chun ; Lee, Yuan Chin Amy ; Hashibe, Mia ; Boccia, Stefania. / Adult height and head and neck cancer : A pooled analysis within the INHANCE Consortium. In: European Journal of Epidemiology. 2014 ; Vol. 29, No. 1. pp. 35-48.
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abstract = "Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 {\%} confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 {\%} CI 0.86-0.95 for men; adjusted OR = 0.86, 95 {\%} CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.",
author = "Emanuele Leoncini and Walter Ricciardi and Gabriella Cadoni and Dario Arzani and Livia Petrelli and Gaetano Paludetti and Paul Brennan and Daniele Luce and Isabelle Stucker and Keitaro Matsuo and Renato Talamini and {La Vecchia}, Carlo and Olshan, {Andrew F.} and Winn, {Deborah M.} and Rolando Herrero and Silvia Franceschi and Xavier Castellsague and Joshua Muscat and Hal Morgenstern and Zhang, {Zuo Feng} and Fabio Levi and {Dal Maso}, Luigino and Karl Kelsey and Michael McClean and Vaughan, {Thomas L.} and Philip Lazarus and Purdue, {Mark P.} and Hayes, {Richard B.} and Chu Chen and Schwartz, {Stephen M.} and Oxana Shangina and Sergio Koifman and Wolfgang Ahrens and Elena Matos and Pagona Lagiou and Jolanta Lissowska and Neonila Szeszenia-Dabrowska and Leticia Fernandez and Ana Menezes and Antonio Agudo and Daudt, {Alexander W.} and Lorenzo Richiardi and Kristina Kjaerheim and Dana Mates and Jaroslav Betka and Yu, {Guo Pei} and Stimson Schantz and Lorenzo Simonato and Hermann Brenner and Conway, {David I.} and Macfarlane, {Tatiana V.} and Peter Thomson and Eleonora Fabianova and Ariana Znaor and Peter Rudnai and Claire Healy and Paolo Boffetta and Chuang, {Shu Chun} and Lee, {Yuan Chin Amy} and Mia Hashibe and Stefania Boccia",
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Leoncini, E, Ricciardi, W, Cadoni, G, Arzani, D, Petrelli, L, Paludetti, G, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, AF, Winn, DM, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, ZF, Levi, F, Dal Maso, L, Kelsey, K, McClean, M, Vaughan, TL, Lazarus, P, Purdue, MP, Hayes, RB, Chen, C, Schwartz, SM, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia-Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, AW, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, GP, Schantz, S, Simonato, L, Brenner, H, Conway, DI, Macfarlane, TV, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, SC, Lee, YCA, Hashibe, M & Boccia, S 2014, 'Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium', European Journal of Epidemiology, vol. 29, no. 1, pp. 35-48. https://doi.org/10.1007/s10654-013-9863-2

Adult height and head and neck cancer : A pooled analysis within the INHANCE Consortium. / Leoncini, Emanuele; Ricciardi, Walter; Cadoni, Gabriella; Arzani, Dario; Petrelli, Livia; Paludetti, Gaetano; Brennan, Paul; Luce, Daniele; Stucker, Isabelle; Matsuo, Keitaro; Talamini, Renato; La Vecchia, Carlo; Olshan, Andrew F.; Winn, Deborah M.; Herrero, Rolando; Franceschi, Silvia; Castellsague, Xavier; Muscat, Joshua; Morgenstern, Hal; Zhang, Zuo Feng; Levi, Fabio; Dal Maso, Luigino; Kelsey, Karl; McClean, Michael; Vaughan, Thomas L.; Lazarus, Philip; Purdue, Mark P.; Hayes, Richard B.; Chen, Chu; Schwartz, Stephen M.; Shangina, Oxana; Koifman, Sergio; Ahrens, Wolfgang; Matos, Elena; Lagiou, Pagona; Lissowska, Jolanta; Szeszenia-Dabrowska, Neonila; Fernandez, Leticia; Menezes, Ana; Agudo, Antonio; Daudt, Alexander W.; Richiardi, Lorenzo; Kjaerheim, Kristina; Mates, Dana; Betka, Jaroslav; Yu, Guo Pei; Schantz, Stimson; Simonato, Lorenzo; Brenner, Hermann; Conway, David I.; Macfarlane, Tatiana V.; Thomson, Peter; Fabianova, Eleonora; Znaor, Ariana; Rudnai, Peter; Healy, Claire; Boffetta, Paolo; Chuang, Shu Chun; Lee, Yuan Chin Amy; Hashibe, Mia; Boccia, Stefania.

In: European Journal of Epidemiology, Vol. 29, No. 1, 01.01.2014, p. 35-48.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Adult height and head and neck cancer

T2 - A pooled analysis within the INHANCE Consortium

AU - Leoncini, Emanuele

AU - Ricciardi, Walter

AU - Cadoni, Gabriella

AU - Arzani, Dario

AU - Petrelli, Livia

AU - Paludetti, Gaetano

AU - Brennan, Paul

AU - Luce, Daniele

AU - Stucker, Isabelle

AU - Matsuo, Keitaro

AU - Talamini, Renato

AU - La Vecchia, Carlo

AU - Olshan, Andrew F.

AU - Winn, Deborah M.

AU - Herrero, Rolando

AU - Franceschi, Silvia

AU - Castellsague, Xavier

AU - Muscat, Joshua

AU - Morgenstern, Hal

AU - Zhang, Zuo Feng

AU - Levi, Fabio

AU - Dal Maso, Luigino

AU - Kelsey, Karl

AU - McClean, Michael

AU - Vaughan, Thomas L.

AU - Lazarus, Philip

AU - Purdue, Mark P.

AU - Hayes, Richard B.

AU - Chen, Chu

AU - Schwartz, Stephen M.

AU - Shangina, Oxana

AU - Koifman, Sergio

AU - Ahrens, Wolfgang

AU - Matos, Elena

AU - Lagiou, Pagona

AU - Lissowska, Jolanta

AU - Szeszenia-Dabrowska, Neonila

AU - Fernandez, Leticia

AU - Menezes, Ana

AU - Agudo, Antonio

AU - Daudt, Alexander W.

AU - Richiardi, Lorenzo

AU - Kjaerheim, Kristina

AU - Mates, Dana

AU - Betka, Jaroslav

AU - Yu, Guo Pei

AU - Schantz, Stimson

AU - Simonato, Lorenzo

AU - Brenner, Hermann

AU - Conway, David I.

AU - Macfarlane, Tatiana V.

AU - Thomson, Peter

AU - Fabianova, Eleonora

AU - Znaor, Ariana

AU - Rudnai, Peter

AU - Healy, Claire

AU - Boffetta, Paolo

AU - Chuang, Shu Chun

AU - Lee, Yuan Chin Amy

AU - Hashibe, Mia

AU - Boccia, Stefania

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

AB - Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

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