Abstract
Bone marrow or adipose derived mesenchymal stem cells (MSCs) were used to test the hypothesis that MSCs delivered via circulatory system into developing mice will migrate, home to bone, differentiate into osteoblasts and deposit bone matrix. By using this approach, it was demonstrated that MSCs injected in developing mice will migrate and engraft in the bones of the developing mice. However, the number of cells that migrate to bone is very small and may not be of clinical relevance. To overcome these obstables, cells were preconditioned to bone microenvironment prior to cell delivery to the recipients. Data show that MSCs are transplantable and can be targeted to tissues of interest for possible repair and regeneration of specific tissues.
| Original language | English (US) |
|---|---|
| Number of pages | 1 |
| Journal | MCB Molecular and Cellular Biomechanics |
| Volume | 3 |
| Issue number | 4 |
| State | Published - Dec 1 2006 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Molecular Medicine
- Molecular Biology
- Cell Biology
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Adult stem cells and skeletal repair and regeneration. / Niyibizi, Christopher; Li, Feng; Wang, X.; Liao, X.
In: MCB Molecular and Cellular Biomechanics, Vol. 3, No. 4, 01.12.2006.Research output: Contribution to journal › Article
TY - JOUR
T1 - Adult stem cells and skeletal repair and regeneration
AU - Niyibizi, Christopher
AU - Li, Feng
AU - Wang, X.
AU - Liao, X.
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Bone marrow or adipose derived mesenchymal stem cells (MSCs) were used to test the hypothesis that MSCs delivered via circulatory system into developing mice will migrate, home to bone, differentiate into osteoblasts and deposit bone matrix. By using this approach, it was demonstrated that MSCs injected in developing mice will migrate and engraft in the bones of the developing mice. However, the number of cells that migrate to bone is very small and may not be of clinical relevance. To overcome these obstables, cells were preconditioned to bone microenvironment prior to cell delivery to the recipients. Data show that MSCs are transplantable and can be targeted to tissues of interest for possible repair and regeneration of specific tissues.
AB - Bone marrow or adipose derived mesenchymal stem cells (MSCs) were used to test the hypothesis that MSCs delivered via circulatory system into developing mice will migrate, home to bone, differentiate into osteoblasts and deposit bone matrix. By using this approach, it was demonstrated that MSCs injected in developing mice will migrate and engraft in the bones of the developing mice. However, the number of cells that migrate to bone is very small and may not be of clinical relevance. To overcome these obstables, cells were preconditioned to bone microenvironment prior to cell delivery to the recipients. Data show that MSCs are transplantable and can be targeted to tissues of interest for possible repair and regeneration of specific tissues.
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UR - http://www.scopus.com/inward/citedby.url?scp=33846428818&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33846428818
VL - 3
JO - MCB Molecular and Cellular Biomechanics
JF - MCB Molecular and Cellular Biomechanics
SN - 1556-5297
IS - 4
ER -