Advanced in vivo heteronuclear MRS approaches for studying brain bioenergetics driven by mitochondria

Xiao Hong Zhu, Fei Du, Nanyin Zhang, Yi Zhang, Hao Lei, Xiaoliang Zhang, Hongyan Qiao, Kamil Ugurbil, Wei Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Scopus citations

Abstract

The greatest merit of in vivo magnetic resonance spectroscopy (MRS) methodology used in biomedical research is its ability for noninvasively measuring a variety of metabolites inside a living organ. It, therefore, provides an invaluable tool for determining metabolites, chemical reaction rates and bioenergetics, as well as their dynamic changes in the human and animal. The capability of in vivo MRS is further enhanced at higher magnetic fields because of significant gain in detection sensitivity and improvement in the spectral resolution. Recent progress of in vivo MRS technology has further demonstrated its great potential in many biomedical research areas, particularly in brain research. Here, we provide a review of new developments for in vivo heteronuclear 31P and 17O MRS approaches and their applications in determining the cerebral metabolic rates of oxygen and ATP inside the mitochondria, in both animal and human brains.

Original languageEnglish (US)
Title of host publicationDynamic Brain Imaging
Subtitle of host publicationMulti-Modal Methods and In Vivo Applications
PublisherHumana Press
Pages317-357
Number of pages41
ISBN (Print)9781934115749
DOIs
StatePublished - Jan 1 2009

Publication series

NameMethods in Molecular Biology
Volume489
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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    Zhu, X. H., Du, F., Zhang, N., Zhang, Y., Lei, H., Zhang, X., Qiao, H., Ugurbil, K., & Chen, W. (2009). Advanced in vivo heteronuclear MRS approaches for studying brain bioenergetics driven by mitochondria. In Dynamic Brain Imaging: Multi-Modal Methods and In Vivo Applications (pp. 317-357). (Methods in Molecular Biology; Vol. 489). Humana Press. https://doi.org/10.1007/978-1-59745-543-5_15