Advances in wound-healing assays for probing collective cell migration

Reza Riahi, Yongliang Yang, Donna D. Zhang, Pak Kin Wong

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

Collective cell migration plays essential roles in a wide spectrum of biological processes, such as embryogenesis, tissue regeneration, and cancer metastasis. Numerous wound-healing assays based on mechanical, chemical, optical, and electrical approaches have been developed to create model "wounds" in cell monolayers to study the collective cell migration processes. These approaches can result in different microenvironments for cells to migrate and possess diverse assay characteristics in terms of simplicity, throughput, reproducibility, and multiplexability. In this review, we provide an overview of advances in wound-healing assays and discuss their advantages and limitations in studying collective cell migration.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalJournal of Laboratory Automation
Volume17
Issue number1
DOIs
StatePublished - Dec 1 2012

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Medical Laboratory Technology

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