Advancing cancer research using bioprinting for tumor-on-a-chip platforms

Stephanie Knowlton, Ashwini Joshi, Bekir Yenilmez, Ibrahim Tarik Ozbolat, Chee Kai Chua, Ali Khademhosseini, Savas Tasoglu

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

There is an urgent for a novel approach to cancer research with 1.7 million new cases of cancer occurring every year in the United States of America. Tumor models offer promise as a useful platform for cancer research with-out the need for animal models, but there remains a challenge to fabricate a relevant model which mimics the structure, function and drug response of human tumors. Bioprinting can address this need by fabricating three-dimensional con-structs that mimic tumor heterogeneity, vasculature and spheroid structures. Furthermore, bioprinting can be used to fabricate tissue constructs within microfluidic platforms, forming "tumor-on-a-chip" devices which are ideal for high-throughput testing in a biomimetic microenvironment. Applications of tumors-on-a-chip include facilitating basic research to better understand tumor development, structure and function as well as drug screening to improve the effi-ciency of cancer drug discovery.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalInternational Journal of Bioprinting
Volume2
Issue number2
DOIs
StatePublished - Jan 1 2016

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Materials Science (miscellaneous)
  • Industrial and Manufacturing Engineering

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