Advancing Frontiers in Bone Bioprinting

Nureddin Ashammakhi, Anwarul Hasan, Outi Kaarela, Batzaya Byambaa, Amir Sheikhi, Akhilesh K. Gaharwar, Ali Khademhosseini

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Three-dimensional (3D) bioprinting of cell-laden biomaterials is used to fabricate constructs that can mimic the structure of native tissues. The main techniques used for 3D bioprinting include microextrusion, inkjet, and laser-assisted bioprinting. Bioinks used for bone bioprinting include hydrogels loaded with bioactive ceramics, cells, and growth factors. In this review, a critical overview of the recent literature on various types of bioinks used for bone bioprinting is presented. Major challenges, such as the vascularity, clinically relevant size, and mechanical properties of 3D printed structures, that need to be addressed to successfully use the technology in clinical settings, are discussed. Emerging approaches to solve these problems are reviewed, and future strategies to design customized 3D printed structures are proposed.

Original languageEnglish (US)
Article number1801048
JournalAdvanced Healthcare Materials
Volume8
Issue number7
DOIs
StatePublished - Apr 11 2019

Fingerprint

Bioprinting
Bone
Bone and Bones
Hydrogels
Biocompatible Materials
Biomaterials
Intercellular Signaling Peptides and Proteins
Tissue
Mechanical properties
Lasers
Ceramics
Technology

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Ashammakhi, N., Hasan, A., Kaarela, O., Byambaa, B., Sheikhi, A., Gaharwar, A. K., & Khademhosseini, A. (2019). Advancing Frontiers in Bone Bioprinting. Advanced Healthcare Materials, 8(7), [1801048]. https://doi.org/10.1002/adhm.201801048
Ashammakhi, Nureddin ; Hasan, Anwarul ; Kaarela, Outi ; Byambaa, Batzaya ; Sheikhi, Amir ; Gaharwar, Akhilesh K. ; Khademhosseini, Ali. / Advancing Frontiers in Bone Bioprinting. In: Advanced Healthcare Materials. 2019 ; Vol. 8, No. 7.
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Ashammakhi, N, Hasan, A, Kaarela, O, Byambaa, B, Sheikhi, A, Gaharwar, AK & Khademhosseini, A 2019, 'Advancing Frontiers in Bone Bioprinting', Advanced Healthcare Materials, vol. 8, no. 7, 1801048. https://doi.org/10.1002/adhm.201801048

Advancing Frontiers in Bone Bioprinting. / Ashammakhi, Nureddin; Hasan, Anwarul; Kaarela, Outi; Byambaa, Batzaya; Sheikhi, Amir; Gaharwar, Akhilesh K.; Khademhosseini, Ali.

In: Advanced Healthcare Materials, Vol. 8, No. 7, 1801048, 11.04.2019.

Research output: Contribution to journalReview article

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Ashammakhi N, Hasan A, Kaarela O, Byambaa B, Sheikhi A, Gaharwar AK et al. Advancing Frontiers in Bone Bioprinting. Advanced Healthcare Materials. 2019 Apr 11;8(7). 1801048. https://doi.org/10.1002/adhm.201801048