Advancing treatment for metastatic bone cancer: Consensus recommendations from the second cambridge conference

Robert E. Coleman, Theresa A. Guise, Allan Lipton, G. David Roodman, James R. Berenson, Jean Jacques Body, Brendan F. Boyce, Laura M. Calvi, Peyman Hadji, Eugene V. McCloskey, Fred Saad, Matthew R. Smith, Larry J. Suva, Russell S. Taichman, Robert L. Vessella, Katherine N. Weilbaecher

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Purpose: Summarize current knowledge, critical gaps in knowledge, and recommendations to advance the field of metastatic bone cancer. Experimental Design: A multidisciplinary consensus conference was convened to review recent progress in basic and clinical research, assess critical gaps in current knowledge, and prioritize recommendations to advance research in the next 5 years. The program addressed three principal topics: biology of metastasis, preserving normal bone health, and optimizing bone-targeted therapies. Results: A variety of specific recommendations were identified as important to advance research and clinical care over the next 5 years. Conclusions: Priorities for research in bone biology include characterizing components of the stem cell niche in bone, developing oncogenic immunocompetent animal models of bone metastasis, and investigating the unique contribution of the bone microenvironment to tumor growth and dormancy. Priorities for research in preserving normal bone health include developing methods to measure and characterize disseminating tumor cells, assessing outcomes from the major prevention trials currently in progress, and improving methodologies to assess risks and benefits of treatment. Priorities for optimizing bone-targeted therapies include advancing studies of serum proteomics and genomics to reliably identify patients who will develop bone metastases, enhancing imaging for early detection of bone metastases and early response evaluation, and developing new tests to evaluate response to bone-directed treatments.

Original languageEnglish (US)
Pages (from-to)6387-6395
Number of pages9
JournalClinical Cancer Research
Volume14
Issue number20
DOIs
StatePublished - Oct 15 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Coleman, R. E., Guise, T. A., Lipton, A., Roodman, G. D., Berenson, J. R., Body, J. J., Boyce, B. F., Calvi, L. M., Hadji, P., McCloskey, E. V., Saad, F., Smith, M. R., Suva, L. J., Taichman, R. S., Vessella, R. L., & Weilbaecher, K. N. (2008). Advancing treatment for metastatic bone cancer: Consensus recommendations from the second cambridge conference. Clinical Cancer Research, 14(20), 6387-6395. https://doi.org/10.1158/1078-0432.CCR-08-1572