Adverse Effects of Amiodarone: Pathogenesis, Incidence and Management

Gerald Naccarelli, Robert L. Rinkenberger, Anne H. Dougherty, David M. Fitzgerald

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Amiodarone is an extremely effective antiarrhythmic agent for the treatment of both life-threatening ventricular arrhythmias and refractory supraventricular tachyarrhythmias. Subjective minor side effects are common with amiodarone but rarely require discontinuation of therapy and are often handled by dose reduction. Serious end-organ toxicity, including pulmonry fibrosis and drug-induced hepatitis, have been the most common indications for discontinuing amiodarone therapy in these patients.

Original languageEnglish (US)
Pages (from-to)246-253
Number of pages8
JournalMedical Toxicology and Adverse Drug Experience
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1989

All Science Journal Classification (ASJC) codes

  • Toxicology

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