Adverse reactions to benzodiazepine hypnotics: Spontaneous reporting system

Edward Bixler, A. Kales, B. H. Brubaker, J. D. Kales

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Abstract

The rates of reported adverse drug reactions involving the central nervous system were compared among patients taking any of three benzodiazepine hypnotics: flurazepam, temazepam, and triazolam. These rates, based upon data collected through the spontaneous reporting system of the Food and Drug Administration, were controlled for the number and size of new prescriptions for each drug. In general, triazolam had much higher overall rates than did the other two drugs. Hyperexcitability and withdrawal effects were greatest for triazolam and least for flurazepam. Amnesia was reported almost exclusively with triazolam. Rates for other cognitive as well as affective and other behavioral effects were also much greater for triazolam and about equal for the other two drugs. Finally, daytime sedation was reported slightly more for flurazepam than triazolam and least for temazepam which was also reported most frequently as lacking hypnotic effect.

Original languageEnglish (US)
Pages (from-to)286-300
Number of pages15
JournalPharmacology
Volume35
Issue number5
DOIs
StatePublished - Jan 1 1987

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All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Bixler, E., Kales, A., Brubaker, B. H., & Kales, J. D. (1987). Adverse reactions to benzodiazepine hypnotics: Spontaneous reporting system. Pharmacology, 35(5), 286-300. https://doi.org/10.1159/000138322