Adverse reactions to fluconazole: Illustrative case with focus on desensitization

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fluconazole is an azole antifungal agent. Because it can be taken orally, it is perferred over amphotericin B for long-term treatment. Indications for fluconazole are increasing. Reports of hypersensitivity have been described. If adequate alternative therapy is not available, desensitization may be necessary. Desensitization with fluconazole has not been described. The patient described in this report required fluconazole and was successfully desensitized after manifesting a type 1 hypersensitivity reaction. The patient underwent desensitization during a 15-day period. The starting dose was less than 0.001 dose, with doubling each day. During desensitization, the patient experienced a slight transient rash that resolved with continued therapy. After desensitization, he has continued using fluconazole daily without adverse effects. This report indicates that desensitization to fluconazole can be accomplished safely in selected patients. A suggested desensitization protocol is provided.

Original languageEnglish (US)
Pages (from-to)584-587
Number of pages4
JournalJournal of the American Osteopathic Association
Volume97
Issue number10
DOIs
StatePublished - Oct 1997

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Fluconazole
Immediate Hypersensitivity
Azoles
Antifungal Agents
Amphotericin B
Complementary Therapies
Exanthema
Hypersensitivity
Therapeutics

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

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abstract = "Fluconazole is an azole antifungal agent. Because it can be taken orally, it is perferred over amphotericin B for long-term treatment. Indications for fluconazole are increasing. Reports of hypersensitivity have been described. If adequate alternative therapy is not available, desensitization may be necessary. Desensitization with fluconazole has not been described. The patient described in this report required fluconazole and was successfully desensitized after manifesting a type 1 hypersensitivity reaction. The patient underwent desensitization during a 15-day period. The starting dose was less than 0.001 dose, with doubling each day. During desensitization, the patient experienced a slight transient rash that resolved with continued therapy. After desensitization, he has continued using fluconazole daily without adverse effects. This report indicates that desensitization to fluconazole can be accomplished safely in selected patients. A suggested desensitization protocol is provided.",
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Adverse reactions to fluconazole : Illustrative case with focus on desensitization. / Craig, Timothy J.

In: Journal of the American Osteopathic Association, Vol. 97, No. 10, 10.1997, p. 584-587.

Research output: Contribution to journalArticle

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