Age and sex differences in sympathetic and hemodynamic responses to hypoxia and cold pressor test

Amanda J. Miller, Jian Cui, J. Carter Luck, Lawrence Sinoway, Matthew D. Muller

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Emerging evidence suggests that sympathetic vasoconstriction is lower in young women. We hypothesized that increases in muscle sympathetic nerve activity (MSNA) during acute physiological stressors induce less vasoconstriction in young women compared to young men. Healthy young men (n = 10, 27 ± 1 years), young women (n = 12, 25 ± 1 years), and older women (n = 10, 63 ± 6 years) performed the cold pressor test (hand in ice for 2 min) and continuous hypoxia (10% O 2 , 90% N 2 ) for 5 min. MSNA, femoral blood flow velocity, heart rate, and blood pressure were acquired continuously. Femoral artery diameter was obtained every minute and used to calculate femoral blood flow, and femoral vascular resistance and conductance. MSNA responses to cold pressor test (P = 0.345) and hypoxia (P = 0.969) were not different between groups. Young women had greater femoral blood flow (P = 0.002) and vascular conductance (P = 0.041) responses to cold pressor test compared with young men. The femoral blood flow response to hypoxia was not different between the two sexes but the increase in femoral flow was attenuated in older women compared with younger women (P = 0.036). These data show that young women had paradoxical vasodilation to cold pressor test. The mechanisms responsible for the attenuated sympathetic vasoconstriction or for enhanced vasodilation in young women during the CPT require further investigation.

Original languageEnglish (US)
Article numbere13988
JournalPhysiological reports
Volume7
Issue number2
DOIs
StatePublished - Jan 1 2019

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Sex Characteristics
Hemodynamics
Thigh
Vasoconstriction
Vasodilation
Muscles
Femoral Nerve
Hypoxia
Blood Flow Velocity
Ice
Femoral Artery
Vascular Resistance
Blood Vessels
Hand
Heart Rate
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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title = "Age and sex differences in sympathetic and hemodynamic responses to hypoxia and cold pressor test",
abstract = "Emerging evidence suggests that sympathetic vasoconstriction is lower in young women. We hypothesized that increases in muscle sympathetic nerve activity (MSNA) during acute physiological stressors induce less vasoconstriction in young women compared to young men. Healthy young men (n = 10, 27 ± 1 years), young women (n = 12, 25 ± 1 years), and older women (n = 10, 63 ± 6 years) performed the cold pressor test (hand in ice for 2 min) and continuous hypoxia (10{\%} O 2 , 90{\%} N 2 ) for 5 min. MSNA, femoral blood flow velocity, heart rate, and blood pressure were acquired continuously. Femoral artery diameter was obtained every minute and used to calculate femoral blood flow, and femoral vascular resistance and conductance. MSNA responses to cold pressor test (P = 0.345) and hypoxia (P = 0.969) were not different between groups. Young women had greater femoral blood flow (P = 0.002) and vascular conductance (P = 0.041) responses to cold pressor test compared with young men. The femoral blood flow response to hypoxia was not different between the two sexes but the increase in femoral flow was attenuated in older women compared with younger women (P = 0.036). These data show that young women had paradoxical vasodilation to cold pressor test. The mechanisms responsible for the attenuated sympathetic vasoconstriction or for enhanced vasodilation in young women during the CPT require further investigation.",
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Age and sex differences in sympathetic and hemodynamic responses to hypoxia and cold pressor test. / Miller, Amanda J.; Cui, Jian; Luck, J. Carter; Sinoway, Lawrence; Muller, Matthew D.

In: Physiological reports, Vol. 7, No. 2, e13988, 01.01.2019.

Research output: Contribution to journalArticle

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