Age and stage as determinants of treatment for oral cavity and oropharyngeal cancers in the elderly

David Goldenberg, Heath Mackley, Wayne Koch, Darrin V. Bann, Eric W. Schaefer, Christopher S. Hollenbeak

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background We investigate treatment selection for oral cavity and oropharyngeal (OC&OP) cancers to understand factors that influence treatment selection. Methods We studied 7023 patients, ≥66 years, diagnosed with a first primary OC&OP cancer using SEER-Medicare data. Multinomial logistic regression was to model treatment selection, controlling for other factors. Results Most patients with OC cancer were treated with surgery alone (56.5%); most patients with OP cancer were treated with chemotherapy and radiation (28.9%). Age, stage and site were the most important predictors of treatment selection. As age increased from 70 to 81 (the interquartile range), treatment shifted toward surgery alone (OR = 1.26; CI: 1.08-1.46) and no treatment (OR = 1.5, 95% CI: 1.25-1.80), and away from combined surgery, radiation and treatments involving chemotherapy. Conclusions Age, stage, and site are the most important determinants of treatment selection for patients with OC&OP cancers. Increasing age and stage drive treatment toward non-surgical options and no treatment at all.

Original languageEnglish (US)
Pages (from-to)976-982
Number of pages7
JournalOral Oncology
Volume50
Issue number10
DOIs
StatePublished - Oct 1 2014

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Oropharyngeal Neoplasms
Mouth Neoplasms
Mouth
Therapeutics
Neoplasms
Radiation
Drug Therapy
Medicare
Patient Selection
Logistic Models

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

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title = "Age and stage as determinants of treatment for oral cavity and oropharyngeal cancers in the elderly",
abstract = "Background We investigate treatment selection for oral cavity and oropharyngeal (OC&OP) cancers to understand factors that influence treatment selection. Methods We studied 7023 patients, ≥66 years, diagnosed with a first primary OC&OP cancer using SEER-Medicare data. Multinomial logistic regression was to model treatment selection, controlling for other factors. Results Most patients with OC cancer were treated with surgery alone (56.5{\%}); most patients with OP cancer were treated with chemotherapy and radiation (28.9{\%}). Age, stage and site were the most important predictors of treatment selection. As age increased from 70 to 81 (the interquartile range), treatment shifted toward surgery alone (OR = 1.26; CI: 1.08-1.46) and no treatment (OR = 1.5, 95{\%} CI: 1.25-1.80), and away from combined surgery, radiation and treatments involving chemotherapy. Conclusions Age, stage, and site are the most important determinants of treatment selection for patients with OC&OP cancers. Increasing age and stage drive treatment toward non-surgical options and no treatment at all.",
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Age and stage as determinants of treatment for oral cavity and oropharyngeal cancers in the elderly. / Goldenberg, David; Mackley, Heath; Koch, Wayne; Bann, Darrin V.; Schaefer, Eric W.; Hollenbeak, Christopher S.

In: Oral Oncology, Vol. 50, No. 10, 01.10.2014, p. 976-982.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Goldenberg, David

AU - Mackley, Heath

AU - Koch, Wayne

AU - Bann, Darrin V.

AU - Schaefer, Eric W.

AU - Hollenbeak, Christopher S.

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N2 - Background We investigate treatment selection for oral cavity and oropharyngeal (OC&OP) cancers to understand factors that influence treatment selection. Methods We studied 7023 patients, ≥66 years, diagnosed with a first primary OC&OP cancer using SEER-Medicare data. Multinomial logistic regression was to model treatment selection, controlling for other factors. Results Most patients with OC cancer were treated with surgery alone (56.5%); most patients with OP cancer were treated with chemotherapy and radiation (28.9%). Age, stage and site were the most important predictors of treatment selection. As age increased from 70 to 81 (the interquartile range), treatment shifted toward surgery alone (OR = 1.26; CI: 1.08-1.46) and no treatment (OR = 1.5, 95% CI: 1.25-1.80), and away from combined surgery, radiation and treatments involving chemotherapy. Conclusions Age, stage, and site are the most important determinants of treatment selection for patients with OC&OP cancers. Increasing age and stage drive treatment toward non-surgical options and no treatment at all.

AB - Background We investigate treatment selection for oral cavity and oropharyngeal (OC&OP) cancers to understand factors that influence treatment selection. Methods We studied 7023 patients, ≥66 years, diagnosed with a first primary OC&OP cancer using SEER-Medicare data. Multinomial logistic regression was to model treatment selection, controlling for other factors. Results Most patients with OC cancer were treated with surgery alone (56.5%); most patients with OP cancer were treated with chemotherapy and radiation (28.9%). Age, stage and site were the most important predictors of treatment selection. As age increased from 70 to 81 (the interquartile range), treatment shifted toward surgery alone (OR = 1.26; CI: 1.08-1.46) and no treatment (OR = 1.5, 95% CI: 1.25-1.80), and away from combined surgery, radiation and treatments involving chemotherapy. Conclusions Age, stage, and site are the most important determinants of treatment selection for patients with OC&OP cancers. Increasing age and stage drive treatment toward non-surgical options and no treatment at all.

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