25 Citations (Scopus)

Abstract

To determine whether survival outcomes of younger patients with oral cavity squamous cell cancer (OSCC) differs from older patients in the US. A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) registry. We studied cases (n = 19681) of OSCC diagnosed from 1973 to 1999 and used age cutoffs at 40, 45, 50, and 55 years. Control groups of older patients were retrospectively matched on gender, race, cancer subsite, and stage of disease. Survival was estimated using the Kaplan-Meier method. A propensity score matching produced groups with similar distributions of patient and disease characteristics. Between these matched groups, younger patients had a significantly better five-year survival (age 40: 63.4% vs. 80.6%, p < 0.0001; age 45: 59.0% vs. 72.8%, p < 0.0001; age 50: 55.5% vs. 67.2%, p < 0.0001; age 55: 54.0% vs. 64.3%, p < 0.0001). These results confirm recent results using population-based data that suggest better overall survival in younger patients.

Original languageEnglish (US)
JournalOral Oncology
Volume45
Issue number8
DOIs
StatePublished - Aug 1 2009

Fingerprint

Mouth Neoplasms
Squamous Cell Neoplasms
Survival
Mouth
Propensity Score
Registries
Epidemiology
Cohort Studies
Research Design
Retrospective Studies
Control Groups
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

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abstract = "To determine whether survival outcomes of younger patients with oral cavity squamous cell cancer (OSCC) differs from older patients in the US. A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) registry. We studied cases (n = 19681) of OSCC diagnosed from 1973 to 1999 and used age cutoffs at 40, 45, 50, and 55 years. Control groups of older patients were retrospectively matched on gender, race, cancer subsite, and stage of disease. Survival was estimated using the Kaplan-Meier method. A propensity score matching produced groups with similar distributions of patient and disease characteristics. Between these matched groups, younger patients had a significantly better five-year survival (age 40: 63.4{\%} vs. 80.6{\%}, p < 0.0001; age 45: 59.0{\%} vs. 72.8{\%}, p < 0.0001; age 50: 55.5{\%} vs. 67.2{\%}, p < 0.0001; age 55: 54.0{\%} vs. 64.3{\%}, p < 0.0001). These results confirm recent results using population-based data that suggest better overall survival in younger patients.",
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Age as a determinant of outcomes for patients with oral cancer. / Goldenberg, David; Brooksby, Craig; Hollenbeak, Christopher S.

In: Oral Oncology, Vol. 45, No. 8, 01.08.2009.

Research output: Contribution to journalArticle

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T1 - Age as a determinant of outcomes for patients with oral cancer

AU - Goldenberg, David

AU - Brooksby, Craig

AU - Hollenbeak, Christopher S.

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N2 - To determine whether survival outcomes of younger patients with oral cavity squamous cell cancer (OSCC) differs from older patients in the US. A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) registry. We studied cases (n = 19681) of OSCC diagnosed from 1973 to 1999 and used age cutoffs at 40, 45, 50, and 55 years. Control groups of older patients were retrospectively matched on gender, race, cancer subsite, and stage of disease. Survival was estimated using the Kaplan-Meier method. A propensity score matching produced groups with similar distributions of patient and disease characteristics. Between these matched groups, younger patients had a significantly better five-year survival (age 40: 63.4% vs. 80.6%, p < 0.0001; age 45: 59.0% vs. 72.8%, p < 0.0001; age 50: 55.5% vs. 67.2%, p < 0.0001; age 55: 54.0% vs. 64.3%, p < 0.0001). These results confirm recent results using population-based data that suggest better overall survival in younger patients.

AB - To determine whether survival outcomes of younger patients with oral cavity squamous cell cancer (OSCC) differs from older patients in the US. A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) registry. We studied cases (n = 19681) of OSCC diagnosed from 1973 to 1999 and used age cutoffs at 40, 45, 50, and 55 years. Control groups of older patients were retrospectively matched on gender, race, cancer subsite, and stage of disease. Survival was estimated using the Kaplan-Meier method. A propensity score matching produced groups with similar distributions of patient and disease characteristics. Between these matched groups, younger patients had a significantly better five-year survival (age 40: 63.4% vs. 80.6%, p < 0.0001; age 45: 59.0% vs. 72.8%, p < 0.0001; age 50: 55.5% vs. 67.2%, p < 0.0001; age 55: 54.0% vs. 64.3%, p < 0.0001). These results confirm recent results using population-based data that suggest better overall survival in younger patients.

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