Age at hormonal onset of puberty based on luteinizing hormone, inhibin B, and body composition in preadolescent US girls

O. Yaw Addo, Bradley S. Miller, Peter Lee, Mary L. Hediger, John H. Himes

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background:Hormonal indicators could be useful for detecting early pubertal onset, but there is little research on how they are related to puberty in US girls. We determined median age at hormonal onset of puberty based on luteinizing hormone (LH) and inhibin B (InB) and explored the extent to which body composition moderates this timing process.

Methods:We analyzed anthropometric and hormone data of 698 US peri-pubertal girls ages 6-11.99 y who had participated in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.

Results:Median age of hormonal onset of puberty was 10.43 y by LH and 10.08 y by InB cut-offs (1.04 mIU/ml for LH and 17.89 pg/ml for InB). Postnatal weight gain modulated onset, making it earlier by 10-11 mo among the highest (greater than +1 SD) relative to normal weight gainers. Onset occurred first in non-Hispanic black (NHB) girls, 10.08 y (95% confidence interval (CI): 10.07-10.09), followed by Mexican-American (MXAM) at 10.64 y (95% CI: 10.63-10.65), and at 10.66 y (95% CI: 10.66-10.67) for non-Hispanic white (NHW) girls using LH. With InB, onset occurred first in MXAM girls at 9.9 y, and at 10.3 y and 10.4 y for their NHB and NHW peers, respectively.

Conclusion:Preadolescent weight gain lowers the age at hormonal onset as defined by LH concentrations. Preventing obesity in childhood may also avert the earlier initiation of the maturation process even at the hormonal level.

Original languageEnglish (US)
Pages (from-to)564-570
Number of pages7
JournalPediatric Research
Volume76
Issue number6
DOIs
StatePublished - Dec 18 2014

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Puberty
Luteinizing Hormone
Body Composition
Age of Onset
Nutrition Surveys
Confidence Intervals
Weight Gain
Pediatric Obesity
inhibin B
Hormones
Weights and Measures
Research

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Addo, O. Yaw ; Miller, Bradley S. ; Lee, Peter ; Hediger, Mary L. ; Himes, John H. / Age at hormonal onset of puberty based on luteinizing hormone, inhibin B, and body composition in preadolescent US girls. In: Pediatric Research. 2014 ; Vol. 76, No. 6. pp. 564-570.
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abstract = "Background:Hormonal indicators could be useful for detecting early pubertal onset, but there is little research on how they are related to puberty in US girls. We determined median age at hormonal onset of puberty based on luteinizing hormone (LH) and inhibin B (InB) and explored the extent to which body composition moderates this timing process.Methods:We analyzed anthropometric and hormone data of 698 US peri-pubertal girls ages 6-11.99 y who had participated in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.Results:Median age of hormonal onset of puberty was 10.43 y by LH and 10.08 y by InB cut-offs (1.04 mIU/ml for LH and 17.89 pg/ml for InB). Postnatal weight gain modulated onset, making it earlier by 10-11 mo among the highest (greater than +1 SD) relative to normal weight gainers. Onset occurred first in non-Hispanic black (NHB) girls, 10.08 y (95{\%} confidence interval (CI): 10.07-10.09), followed by Mexican-American (MXAM) at 10.64 y (95{\%} CI: 10.63-10.65), and at 10.66 y (95{\%} CI: 10.66-10.67) for non-Hispanic white (NHW) girls using LH. With InB, onset occurred first in MXAM girls at 9.9 y, and at 10.3 y and 10.4 y for their NHB and NHW peers, respectively.Conclusion:Preadolescent weight gain lowers the age at hormonal onset as defined by LH concentrations. Preventing obesity in childhood may also avert the earlier initiation of the maturation process even at the hormonal level.",
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Age at hormonal onset of puberty based on luteinizing hormone, inhibin B, and body composition in preadolescent US girls. / Addo, O. Yaw; Miller, Bradley S.; Lee, Peter; Hediger, Mary L.; Himes, John H.

In: Pediatric Research, Vol. 76, No. 6, 18.12.2014, p. 564-570.

Research output: Contribution to journalArticle

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T1 - Age at hormonal onset of puberty based on luteinizing hormone, inhibin B, and body composition in preadolescent US girls

AU - Addo, O. Yaw

AU - Miller, Bradley S.

AU - Lee, Peter

AU - Hediger, Mary L.

AU - Himes, John H.

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N2 - Background:Hormonal indicators could be useful for detecting early pubertal onset, but there is little research on how they are related to puberty in US girls. We determined median age at hormonal onset of puberty based on luteinizing hormone (LH) and inhibin B (InB) and explored the extent to which body composition moderates this timing process.Methods:We analyzed anthropometric and hormone data of 698 US peri-pubertal girls ages 6-11.99 y who had participated in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.Results:Median age of hormonal onset of puberty was 10.43 y by LH and 10.08 y by InB cut-offs (1.04 mIU/ml for LH and 17.89 pg/ml for InB). Postnatal weight gain modulated onset, making it earlier by 10-11 mo among the highest (greater than +1 SD) relative to normal weight gainers. Onset occurred first in non-Hispanic black (NHB) girls, 10.08 y (95% confidence interval (CI): 10.07-10.09), followed by Mexican-American (MXAM) at 10.64 y (95% CI: 10.63-10.65), and at 10.66 y (95% CI: 10.66-10.67) for non-Hispanic white (NHW) girls using LH. With InB, onset occurred first in MXAM girls at 9.9 y, and at 10.3 y and 10.4 y for their NHB and NHW peers, respectively.Conclusion:Preadolescent weight gain lowers the age at hormonal onset as defined by LH concentrations. Preventing obesity in childhood may also avert the earlier initiation of the maturation process even at the hormonal level.

AB - Background:Hormonal indicators could be useful for detecting early pubertal onset, but there is little research on how they are related to puberty in US girls. We determined median age at hormonal onset of puberty based on luteinizing hormone (LH) and inhibin B (InB) and explored the extent to which body composition moderates this timing process.Methods:We analyzed anthropometric and hormone data of 698 US peri-pubertal girls ages 6-11.99 y who had participated in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.Results:Median age of hormonal onset of puberty was 10.43 y by LH and 10.08 y by InB cut-offs (1.04 mIU/ml for LH and 17.89 pg/ml for InB). Postnatal weight gain modulated onset, making it earlier by 10-11 mo among the highest (greater than +1 SD) relative to normal weight gainers. Onset occurred first in non-Hispanic black (NHB) girls, 10.08 y (95% confidence interval (CI): 10.07-10.09), followed by Mexican-American (MXAM) at 10.64 y (95% CI: 10.63-10.65), and at 10.66 y (95% CI: 10.66-10.67) for non-Hispanic white (NHW) girls using LH. With InB, onset occurred first in MXAM girls at 9.9 y, and at 10.3 y and 10.4 y for their NHB and NHW peers, respectively.Conclusion:Preadolescent weight gain lowers the age at hormonal onset as defined by LH concentrations. Preventing obesity in childhood may also avert the earlier initiation of the maturation process even at the hormonal level.

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