Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women

Timothy Mosher, Yi Liu, Qing Yang, Jing Yao, Ryan Smith, Bernard J. Dardzinski, Michael B. Smith

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Objective. Because the magnetic resonance imaging (MRI) transverse relaxation time (T2) of cartilage is sensitive to organization of collagen fibers in the cartilage, it may be a noninvasive image marker for senescent changes in cartilage collagen and early cartilage degeneration. The purpose of this study was to determine age-dependent differences in cartilage T2 values in healthy asymptomatic women. Methods. Quantitative T2 maps of patellar cartilage from 30 asymptomatic women ages 22-86 years were obtained using a 3.0T MRI scanner. The study population was stratified by age into 4 cohorts: 18-30, 31-45, 46-65, and 66-86 years. Spatial differences in cartilage T2 were determined as a function of normalised distance from bone. Older groups were compared with the 18-30-year-old group to determine the effects of age on cartilage T2 values. Regions were considered statistically significantly different if the mean T2 values between groups differed at P < 0.05. Results. Mean cartilage T2 profiles were nearly identical for the 2 youngest cohorts. Compared with the 18-30-year-old group, T2 values were statistically significantly longer in the superficial 40% of cartilage in the 46-65-year-old group and over the entire cartilage thickness in the 66-86-year-old group. Conclusion. The location of T2 elevations in women over the age of 45 years is consistent with the theory that senescent changes of cartilage collagen begin near the articular surface and progress to the deeper cartilage with advancing age.

Original languageEnglish (US)
Pages (from-to)2820-2828
Number of pages9
JournalArthritis and rheumatism
Volume50
Issue number9
DOIs
StatePublished - Sep 1 2004

Fingerprint

Cartilage
Magnetic Resonance Imaging
Collagen
Joints
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Mosher, Timothy ; Liu, Yi ; Yang, Qing ; Yao, Jing ; Smith, Ryan ; Dardzinski, Bernard J. ; Smith, Michael B. / Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. In: Arthritis and rheumatism. 2004 ; Vol. 50, No. 9. pp. 2820-2828.
@article{1449eedfc8e842188ac45f2e7f52982f,
title = "Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women",
abstract = "Objective. Because the magnetic resonance imaging (MRI) transverse relaxation time (T2) of cartilage is sensitive to organization of collagen fibers in the cartilage, it may be a noninvasive image marker for senescent changes in cartilage collagen and early cartilage degeneration. The purpose of this study was to determine age-dependent differences in cartilage T2 values in healthy asymptomatic women. Methods. Quantitative T2 maps of patellar cartilage from 30 asymptomatic women ages 22-86 years were obtained using a 3.0T MRI scanner. The study population was stratified by age into 4 cohorts: 18-30, 31-45, 46-65, and 66-86 years. Spatial differences in cartilage T2 were determined as a function of normalised distance from bone. Older groups were compared with the 18-30-year-old group to determine the effects of age on cartilage T2 values. Regions were considered statistically significantly different if the mean T2 values between groups differed at P < 0.05. Results. Mean cartilage T2 profiles were nearly identical for the 2 youngest cohorts. Compared with the 18-30-year-old group, T2 values were statistically significantly longer in the superficial 40{\%} of cartilage in the 46-65-year-old group and over the entire cartilage thickness in the 66-86-year-old group. Conclusion. The location of T2 elevations in women over the age of 45 years is consistent with the theory that senescent changes of cartilage collagen begin near the articular surface and progress to the deeper cartilage with advancing age.",
author = "Timothy Mosher and Yi Liu and Qing Yang and Jing Yao and Ryan Smith and Dardzinski, {Bernard J.} and Smith, {Michael B.}",
year = "2004",
month = "9",
day = "1",
doi = "10.1002/art.20473",
language = "English (US)",
volume = "50",
pages = "2820--2828",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. / Mosher, Timothy; Liu, Yi; Yang, Qing; Yao, Jing; Smith, Ryan; Dardzinski, Bernard J.; Smith, Michael B.

In: Arthritis and rheumatism, Vol. 50, No. 9, 01.09.2004, p. 2820-2828.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women

AU - Mosher, Timothy

AU - Liu, Yi

AU - Yang, Qing

AU - Yao, Jing

AU - Smith, Ryan

AU - Dardzinski, Bernard J.

AU - Smith, Michael B.

PY - 2004/9/1

Y1 - 2004/9/1

N2 - Objective. Because the magnetic resonance imaging (MRI) transverse relaxation time (T2) of cartilage is sensitive to organization of collagen fibers in the cartilage, it may be a noninvasive image marker for senescent changes in cartilage collagen and early cartilage degeneration. The purpose of this study was to determine age-dependent differences in cartilage T2 values in healthy asymptomatic women. Methods. Quantitative T2 maps of patellar cartilage from 30 asymptomatic women ages 22-86 years were obtained using a 3.0T MRI scanner. The study population was stratified by age into 4 cohorts: 18-30, 31-45, 46-65, and 66-86 years. Spatial differences in cartilage T2 were determined as a function of normalised distance from bone. Older groups were compared with the 18-30-year-old group to determine the effects of age on cartilage T2 values. Regions were considered statistically significantly different if the mean T2 values between groups differed at P < 0.05. Results. Mean cartilage T2 profiles were nearly identical for the 2 youngest cohorts. Compared with the 18-30-year-old group, T2 values were statistically significantly longer in the superficial 40% of cartilage in the 46-65-year-old group and over the entire cartilage thickness in the 66-86-year-old group. Conclusion. The location of T2 elevations in women over the age of 45 years is consistent with the theory that senescent changes of cartilage collagen begin near the articular surface and progress to the deeper cartilage with advancing age.

AB - Objective. Because the magnetic resonance imaging (MRI) transverse relaxation time (T2) of cartilage is sensitive to organization of collagen fibers in the cartilage, it may be a noninvasive image marker for senescent changes in cartilage collagen and early cartilage degeneration. The purpose of this study was to determine age-dependent differences in cartilage T2 values in healthy asymptomatic women. Methods. Quantitative T2 maps of patellar cartilage from 30 asymptomatic women ages 22-86 years were obtained using a 3.0T MRI scanner. The study population was stratified by age into 4 cohorts: 18-30, 31-45, 46-65, and 66-86 years. Spatial differences in cartilage T2 were determined as a function of normalised distance from bone. Older groups were compared with the 18-30-year-old group to determine the effects of age on cartilage T2 values. Regions were considered statistically significantly different if the mean T2 values between groups differed at P < 0.05. Results. Mean cartilage T2 profiles were nearly identical for the 2 youngest cohorts. Compared with the 18-30-year-old group, T2 values were statistically significantly longer in the superficial 40% of cartilage in the 46-65-year-old group and over the entire cartilage thickness in the 66-86-year-old group. Conclusion. The location of T2 elevations in women over the age of 45 years is consistent with the theory that senescent changes of cartilage collagen begin near the articular surface and progress to the deeper cartilage with advancing age.

UR - http://www.scopus.com/inward/record.url?scp=4444220234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444220234&partnerID=8YFLogxK

U2 - 10.1002/art.20473

DO - 10.1002/art.20473

M3 - Article

C2 - 15457450

AN - SCOPUS:4444220234

VL - 50

SP - 2820

EP - 2828

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 9

ER -