Age of thelarche and menarche in contemporary US females: A cross-sectional analysis

Susanne M. Cabrera, George M. Bright, James W. Frane, Sandra L. Blethen, Peter Lee

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Aim: A recent secular trend towards earlier thelarche has been suggested. The aim of this study is to examine normative ages of thelarche and menarche in contemporary US females. Methods: Trained physicians documented Tanner breast stage by observation in a cross-sectional cohort. Age of menarche was self-reported. The subjects were healthy female children and adolescents. The mean age of thelarche was determined by probit analysis and the mean age of menarche was determined by using a normal time-to-event model. Results: Mean age of thelarche was 9.7 years among 610 females aged 3.0-17.9 years (70% non-Hispanic Caucasian (NHC), 14% African-Americans, 7% Hispanic, 9% "other"). The mean age of menarche was 12.8 years for NHC, with African-Americans having menarche 0.6 years earlier. Conclusions: Thelarche occurred earlier than recently reported, while age of menarche remained unchanged, this supported a persistent secular trend towards earlier thelarche but stable age of menarche. This suggests that the observed thelarche is gonadotropin-independent or the tempo of pubertal advancement has slowed.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Volume27
Issue number1-2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Menarche
Cross-Sectional Studies
African Americans
Gonadotropins
Hispanic Americans
Healthy Volunteers
Breast
Observation
Physicians

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Cabrera, Susanne M. ; Bright, George M. ; Frane, James W. ; Blethen, Sandra L. ; Lee, Peter. / Age of thelarche and menarche in contemporary US females : A cross-sectional analysis. In: Journal of Pediatric Endocrinology and Metabolism. 2014 ; Vol. 27, No. 1-2. pp. 47-51.
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Age of thelarche and menarche in contemporary US females : A cross-sectional analysis. / Cabrera, Susanne M.; Bright, George M.; Frane, James W.; Blethen, Sandra L.; Lee, Peter.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 27, No. 1-2, 01.01.2014, p. 47-51.

Research output: Contribution to journalArticle

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AU - Lee, Peter

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