Abstract
Compared to young adults, older adults show not only a reduction in true memories but also an increase in false memories. We investigated the neural bases of these age effects using functional magnetic resonance imaging and a false memory task that resembles the Deese-Roediger-McDermott (DRM) paradigm. Young and older participants were scanned during a word recognition task that included studied words and new words that were strongly associated with studied words (critical lures). During correct recognition of studied words (true memory), older adults showed weaker activity than young adults in the hippocampus but stronger activity than young adults in the retrosplenial cortex. The hippocampal reduction is consistent with age-related deficits in recollection, whereas the retrosplenial increase suggests compensatory recruitment of alternative recollection-related regions. During incorrect recognition of critical lures (false memory), older adults displayed stronger activity than young adults in the left lateral temporal cortex, a region involved in semantic processing and semantic gist. Taken together, the results suggest that older adults' deficits in true memories reflect a decline in recollection processes mediated by the hippocampus, whereas their increased tendency to have false memories reflects their reliance on semantic gist mediated by the lateral temporal cortex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1390-1402 |
| Number of pages | 13 |
| Journal | Journal of cognitive neuroscience |
| Volume | 20 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2008 |
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All Science Journal Classification (ASJC) codes
- Cognitive Neuroscience
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Age-related differences in brain activity during true and false memory retrieval. / Dennis, Nancy A.; Kim, Hongkeun; Cabeza, Roberto.
In: Journal of cognitive neuroscience, Vol. 20, No. 8, 01.08.2008, p. 1390-1402.Research output: Contribution to journal › Article
TY - JOUR
T1 - Age-related differences in brain activity during true and false memory retrieval
AU - Dennis, Nancy A.
AU - Kim, Hongkeun
AU - Cabeza, Roberto
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Compared to young adults, older adults show not only a reduction in true memories but also an increase in false memories. We investigated the neural bases of these age effects using functional magnetic resonance imaging and a false memory task that resembles the Deese-Roediger-McDermott (DRM) paradigm. Young and older participants were scanned during a word recognition task that included studied words and new words that were strongly associated with studied words (critical lures). During correct recognition of studied words (true memory), older adults showed weaker activity than young adults in the hippocampus but stronger activity than young adults in the retrosplenial cortex. The hippocampal reduction is consistent with age-related deficits in recollection, whereas the retrosplenial increase suggests compensatory recruitment of alternative recollection-related regions. During incorrect recognition of critical lures (false memory), older adults displayed stronger activity than young adults in the left lateral temporal cortex, a region involved in semantic processing and semantic gist. Taken together, the results suggest that older adults' deficits in true memories reflect a decline in recollection processes mediated by the hippocampus, whereas their increased tendency to have false memories reflects their reliance on semantic gist mediated by the lateral temporal cortex.
AB - Compared to young adults, older adults show not only a reduction in true memories but also an increase in false memories. We investigated the neural bases of these age effects using functional magnetic resonance imaging and a false memory task that resembles the Deese-Roediger-McDermott (DRM) paradigm. Young and older participants were scanned during a word recognition task that included studied words and new words that were strongly associated with studied words (critical lures). During correct recognition of studied words (true memory), older adults showed weaker activity than young adults in the hippocampus but stronger activity than young adults in the retrosplenial cortex. The hippocampal reduction is consistent with age-related deficits in recollection, whereas the retrosplenial increase suggests compensatory recruitment of alternative recollection-related regions. During incorrect recognition of critical lures (false memory), older adults displayed stronger activity than young adults in the left lateral temporal cortex, a region involved in semantic processing and semantic gist. Taken together, the results suggest that older adults' deficits in true memories reflect a decline in recollection processes mediated by the hippocampus, whereas their increased tendency to have false memories reflects their reliance on semantic gist mediated by the lateral temporal cortex.
UR - http://www.scopus.com/inward/record.url?scp=48749119841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48749119841&partnerID=8YFLogxK
U2 - 10.1162/jocn.2008.20096
DO - 10.1162/jocn.2008.20096
M3 - Article
C2 - 18303982
AN - SCOPUS:48749119841
VL - 20
SP - 1390
EP - 1402
JO - Journal of Cognitive Neuroscience
JF - Journal of Cognitive Neuroscience
SN - 0898-929X
IS - 8
ER -